elastin Antibody (BA-4): sc-58756

Elastin Antibody (BA-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects elastin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-elastin antibody (BA-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Elastin plays a crucial role in providing elasticity and resilience to connective tissues, particularly in the extracellular matrix of arteries, where elastin is essential for maintaining vascular integrity and function. Elastin′s unique structure, characterized by a high content of glycine, proline, and hydrophobic residues, allows elastin to form a rubber-like network through lysine-derived crosslinks, such as desmosines. This structural property is vital for the ability of tissues to stretch and recoil, which is particularly important in organs that undergo significant mechanical stress, such as the lungs and blood vessels. As individuals age, the cross-linking of elastin with collagen can lead to a decrease in tissue elasticity, contributing to various age-related disorders. Furthermore, deficiencies in elastin are linked to serious conditions like supravalvular aortic stenosis and Williams-Beuren syndrome, highlighting elastin′s importance in cardiovascular health. The human elastin gene is located on chromosome 7q11.23, underscoring elastin′s genetic significance in developmental and pathological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

elastin Antibody (BA-4) References:

1. Human elastin gene: new evidence for localization to the long arm of chromosome 7.  |  Fazio, MJ., et al. 1991. Am J Hum Genet. 48: 696-703. PMID: 2014796
2. Matrix metalloproteinase interactions with collagen and elastin.  |  Van Doren, SR. 2015. Matrix Biol. 44-46: 224-31. PMID: 25599938
3. Elastin, arterial mechanics, and cardiovascular disease.  |  Cocciolone, AJ., et al. 2018. Am J Physiol Heart Circ Physiol. 315: H189-H205. PMID: 29631368
4. Elastin-Like Polypeptides for Biomedical Applications.  |  Varanko, AK., et al. 2020. Annu Rev Biomed Eng. 22: 343-369. PMID: 32343908
5. Elastin in the Tumor Microenvironment.  |  Wang, Y., et al. 2020. Adv Exp Med Biol. 1272: 1-16. PMID: 32845499
6. Fibrous Scaffolds From Elastin-Based Materials.  |  Rodriguez-Cabello, JC., et al. 2021. Front Bioeng Biotechnol. 9: 652384. PMID: 34336798
7. Emerging mechanisms of elastin transcriptional regulation.  |  Procknow, SS. and Kozel, BA. 2022. Am J Physiol Cell Physiol. 323: C666-C677. PMID: 35816641
8. Cytokine conjugates to elastin-like polypeptides.  |  Gong, L., et al. 2022. Adv Drug Deliv Rev. 190: 114541. PMID: 36126792
9. Isolation and characterization of desmosine(s) containing peptide fractions of normal and diseases human aortic elastin.  |  Henin-Pizieux, O., et al. 1979. Paroi Arterielle. 5: 41-53. PMID: 492780
10. Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome.  |  Ewart, AK., et al. 1993. Nat Genet. 5: 11-6. PMID: 7693128
11. Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN).  |  Zhang, MC., et al. 1999. J Biol Chem. 274: 981-6. PMID: 9873040

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-elastin Antibody (BA-4) has 36 citations in a variety of scientific publications.

Primary antibodies like Anti-elastin Antibody (BA-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

elastin Antibody (BA-4) Specifications

Alternate Product Name: elastin

Product Clone Name: BA-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: elastin

Epitope Species: bovine

Product Reactivity/Detection: insoluble elastin, α-elastin and soluble non-cross linked precursor of elastin (tropoelastin)

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine, porcine, feline and canine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 36 citations in various scientific publications

Available Conjugates/Forms for elastin Antibody (BA-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin