eIF4AII Antibody (G-5): sc-137147
- eIF4AII Antibody (G-5) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-43 at the N-terminus of eIF4AII of human origin
- recommended for detection of eIF4AII of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for eIF4AII Antibody (G-5) for WB applications. These reagents are now offered in bundles with eIF4AII Antibody (G-5) (see ordering information below).
eIF4AII Antibody (G-5) is a mouse monoclonal IgG2b antibody that detects eIF4AII in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). eIF4AII, also known as DDX2B, plays a crucial role in the translation initiation process by unwinding mRNA secondary structures, thereby facilitating the assembly of the ribosomal complex necessary for protein synthesis. eIF4AII is predominantly located in the cytoplasm, where eIF4AII interacts with other components of the eIF4F complex, including eIF4E and eIF4G, to ensure efficient translation of mRNA. eIF4AII directly influences the regulation of gene expression and protein production, which are essential for cell growth and response to environmental signals. Additionally, eIF4AII is subject to various post-translational modifications, such as phosphorylation, which can affect activity and interactions with other proteins, highlighting eIF4AII′s importance in the dynamic regulation of translation. anti-eIF4AII antibody (G-5) is an invaluable tool for researchers studying the mechanisms of translation and its implications in various biological processes and diseases.
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eIF4AII Antibody (G-5) References:
- Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. | Li, Q., et al. 1999. Mol Cell Biol. 19: 7336-46. PMID: 10523622
- A cellular response linking eIF4AI activity to eIF4AII transcription. | Galicia-Vázquez, G., et al. 2012. RNA. 18: 1373-84. PMID: 22589333
- Downregulation of EIF4A2 in non-small-cell lung cancer associates with poor prognosis. | Shaoyan, X., et al. 2013. Clin Lung Cancer. 14: 658-65. PMID: 23867391
- MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. | Fukao, A., et al. 2014. Mol Cell. 56: 79-89. PMID: 25280105
- Sumoylation of eIF4A2 affects stress granule formation. | Jongjitwimol, J., et al. 2016. J Cell Sci. 129: 2407-15. PMID: 27160682
- eIF4A2 is a host factor required for efficient HIV-1 replication. | Ndzinu, JK., et al. 2018. Microbes Infect. 20: 346-352. PMID: 29842983
- DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. | Meijer, HA., et al. 2019. Nucleic Acids Res. 47: 8224-8238. PMID: 31180491
- High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. | Lyu, S., et al. 2020. Oncol Lett. 20: 177. PMID: 32934744
- Rare EIF4A2 variants are associated with a neurodevelopmental disorder characterized by intellectual disability, hypotonia, and epilepsy. | Paul, MS., et al. 2023. Am J Hum Genet. 110: 120-145. PMID: 36528028
- Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function. | Du, Y., et al. 2025. Cell Mol Immunol. 22: 40-53. PMID: 39516355
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
eIF4AII Antibody (G-5) | sc-137147 | 200 µg/ml | $322.00 | |||
eIF4AII Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-539947 | 200 µg Ab; 10 µg BP | $361.00 | |||
eIF4AII Antibody (G-5): m-IgG2b BP-HRP Bundle | sc-549757 | 200 µg Ab; 10 µg BP | $361.00 | |||
eIF4AII (G-5) Neutralizing Peptide | sc-137147 P | 100 µg/0.5 ml | $69.00 |