eIF3K Antibody (F-4): sc-393234

eIF3K Antibody (F-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects eIF3K protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-eIF3K antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. eIF3K protein, also known as Eukaryotic translation initiation factor 3 subunit K or Muscle-specific gene M9 protein, plays a crucial role in translation initiation, a fundamental process for protein synthesis in cells. As the smallest subunit of the eIF3 complex, eIF3K is essential for the assembly of the 40S ribosomal subunit, facilitating the binding of methionyl-tRNAi and mRNA, and interacting with other initiation factors to form the 40S initiation complex. This protein is highly conserved across various species, including mammals, insects, and plants, and is ubiquitously expressed in human tissues, highlighting its importance in cellular function. eIF3K is located in both the nucleus and cytoplasm, where eIF3K colocalizes with cyclin D3, a key regulatory subunit of cyclin-dependent kinase 4 (Cdk4), indicating its potential involvement in cell cycle regulation and proliferation. anti-eIF3K antibody (F-4) in multiple formats makes this product a versatile tool for researchers studying translation initiation and its implications in various biological processes and diseases.

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eIF3K Antibody (F-4) References:

1. PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.  |  Karki, S., et al. 2002. Mol Biol Cell. 13: 1722-34. PMID: 12006665
2. Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.  |  Mayeur, GL., et al. 2003. Eur J Biochem. 270: 4133-9. PMID: 14519125
3. Crystal structure of human eIF3k, the first structure of eIF3 subunits.  |  Wei, Z., et al. 2004. J Biol Chem. 279: 34983-90. PMID: 15180986
4. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.  |  Shen, X., et al. 2004. FEBS Lett. 573: 139-46. PMID: 15327989
5. Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes.  |  Scheel, H. and Hofmann, K. 2005. BMC Bioinformatics. 6: 71. PMID: 15790418
6. Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k.  |  De Martelaere, K., et al. 2007. Cell Signal. 19: 278-88. PMID: 16935469
7. Methodology for measuring conformation of solvent-disrupted protein subunits using T-WAVE ion mobility MS: an investigation into eukaryotic initiation factors.  |  Leary, JA., et al. 2009. J Am Soc Mass Spectrom. 20: 1699-706. PMID: 19564121
8. Selection of reference genes for quantitative real-time PCR normalisation in adipose tissue, muscle, liver and mammary gland from ruminants.  |  Bonnet, M., et al. 2013. Animal. 7: 1344-53. PMID: 23552195
9. Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.  |  Herrmannová, A., et al. 2020. Nucleic Acids Res. 48: 1969-1984. PMID: 31863585
10. Bioinformatics and network-based approaches for determining pathways, signature molecules, and drug substances connected to genetic basis of schizophrenia etiology.  |  Khan, U., et al. 2022. Brain Res. 1785: 147889. PMID: 35339428
11. Mechanism of the cardioprotective effect of empagliflozin on diabetic nephropathy mice based on the basis of proteomics.  |  Yu, Z., et al. 2024. Proteome Sci. 22: 9. PMID: 39427190
12. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.  |  Asano, K., et al. 1997. J Biol Chem. 272: 27042-52. PMID: 9341143

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-eIF3K Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-eIF3K Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

eIF3K Antibody (F-4) Specifications

Alternate Product Name: eIF3K

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-218

Epitope Target: eIF3K

Epitope Species: human

Product Reactivity/Detection: eIF3K

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for eIF3K Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin