eIF2Bδ Antibody (D-1): sc-271332

eIF2Bδ Antibody (D-1) is a mouse monoclonal IgG2a antibody that detects eIF2Bδ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). eIF2Bδ is a crucial component of the eukaryotic initiation factor 2B complex, which plays a vital role in the regulation of protein synthesis by facilitating the exchange of GDP for GTP on the eIF2 complex. This exchange is essential for the proper assembly of the translation initiation complex, allowing for the accurate initiation of protein synthesis. The eIF2B complex, consisting of five subunits including eIF2Bδ, ensures that the translation process is tightly regulated, responding to cellular stress and nutrient availability. Notably, the phosphorylation of eIF2 can inhibit the guanine nucleotide exchange factor activity of the eIF2B complex, which is a critical mechanism for controlling protein synthesis under stress conditions. Anti-eIF2Bδ antibody (D-1) enables researchers to gain insights into the dynamics of protein synthesis regulation and its implications in various cellular processes and diseases.

The preferred eIF2Bδ antibody is eIF2Bδ Antibody (P-6): sc-9981.