EG-VEGF Antibody (E-12): sc-390741

EG-VEGF Antibody (E-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects EG-VEGF protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-EG-VEGF antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The endocrine gland-derived vascular endothelial growth factor (EG-VEGF) plays a crucial role in the proliferation, migration, and fenestration of capillary endothelial cells specifically derived from endocrine glands, such as the ovary, testis, adrenal glands, and placenta. EG-VEGF includes a high-affinity binding site for hypoxia-inducible factor 1 (HIF-1), allowing expression to be induced under hypoxic conditions and regulate vascular development in a tissue-specific manner. EG-VEGF expression is often complementary to vascular endothelial growth factor (VEGF), suggesting coordinated function between these molecules in promoting endothelial cell behavior. Through binding to a G protein-coupled receptor, EG-VEGF activates critical signaling pathways, including MAPK p44/42 and phosphatidylinositol 3-kinase, which are essential for endothelial cell proliferation, migration, and survival in response to specific physiological cues.

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EG-VEGF Antibody (E-12) References:

1. Cardiovascular biology. Creating unique blood vessels.  |  Carmeliet, P. 2001. Nature. 412: 868-9. PMID: 11528460
2. Identification of an angiogenic mitogen selective for endocrine gland endothelium.  |  LeCouter, J., et al. 2001. Nature. 412: 877-84. PMID: 11528470
3. Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells.  |  Lin, R., et al. 2002. J Biol Chem. 277: 8724-9. PMID: 11751915
4. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.  |  Lin, DC., et al. 2002. J Biol Chem. 277: 19276-80. PMID: 11886876
5. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.  |  Masuda, Y., et al. 2002. Biochem Biophys Res Commun. 293: 396-402. PMID: 12054613
6. Endocrine gland vascular endothelial growth factor (EG-VEGF) and the hypothesis of tissue-specific regulation of angiogenesis.  |  Ferrara, N., et al. 2002. Endocr Res. 28: 763-4. PMID: 12530695
7. EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors.  |  Ferrara, N., et al. 2004. Biochim Biophys Acta. 1654: 69-78. PMID: 14984768
8. EG-VEGF: a novel mediator of endocrine-specific angiogenesis, endothelial phenotype, and function.  |  Lecouter, J., et al. 2004. Ann N Y Acad Sci. 1014: 50-7. PMID: 15153419
9. EG-VEGF: a key endocrine factor in placental development.  |  Brouillet, S., et al. 2012. Trends Endocrinol Metab. 23: 501-8. PMID: 22709436
10. EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway.  |  Yan, X., et al. 2019. Biomed Pharmacother. 109: 762-769. PMID: 30551529
11. VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas.  |  Corlan, AS., et al. 2019. Eur J Histochem. 63: PMID: 30838843
12. EG-VEGF Induces Invasion of a Human Trophoblast Cell Line via PROKR2.  |  Tani, K., et al. 2021. Acta Med Okayama. 75: 677-684. PMID: 34955534

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EG-VEGF Antibody (E-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-EG-VEGF Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EG-VEGF Antibody (E-12) Specifications

Alternate Product Name: EG-VEGF

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 66-105

Epitope Target: EG-VEGF

Epitope Species: human

Product Reactivity/Detection: precursor and mature EG-VEGF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for EG-VEGF Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin