EDG-7 Antibody (C-7): sc-390270

EDG-7 Antibody (C-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects EDG-7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EDG-7 (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EDG-7 protein, also known as LPAR3 or LPA3, is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors, which play a crucial role in mediating the effects of lysophosphatidic acid (LPA) and other lysophospholipid mediators. These receptors are integral to various cellular processes, including cell survival, growth, migration, and differentiation, by coupling to multiple G proteins that activate downstream signaling pathways such as Ras, MAP kinase, and phospholipase C. EDG-7 is primarily expressed in the brain and has been implicated in neuroprotection and the modulation of neuronal responses to injury. Understanding EDG-7 function is essential, as EDG-7 may contribute to therapeutic strategies targeting neurological disorders and other conditions influenced by lysophospholipid signaling.

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EDG-7 Antibody (C-7) References:

1. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.  |  Bandoh, K., et al. 1999. J Biol Chem. 274: 27776-85. PMID: 10488122
2. A subfamily of G protein-coupled cellular receptors for lysophospholipids and lysosphingolipids.  |  Goetzl, EJ. and An, S. 1999. Adv Exp Med Biol. 469: 259-64. PMID: 10667339
3. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate.  |  Im, DS., et al. 2000. Mol Pharmacol. 57: 753-9. PMID: 10727522
4. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.  |  Van Brocklyn, JR., et al. 2000. Blood. 95: 2624-9. PMID: 10753843
5. A novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid with unsaturated fatty-acid moiety.  |  Aoki, J., et al. 2000. Ann N Y Acad Sci. 905: 263-6. PMID: 10818460
6. Sphingosine 1-phosphate signalling in mammalian cells.  |  Pyne, S. and Pyne, NJ. 2000. Biochem J. 349: 385-402. PMID: 10880336
7. Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid.  |  Fitzgerald, LR., et al. 2000. Biochem Biophys Res Commun. 273: 805-10. PMID: 10891327
8. Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells.  |  Sato, K., et al. 2000. Brain Res Mol Brain Res. 85: 151-60. PMID: 11146117
9. Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane.  |  Zheng, Y., et al. 2001. J Immunol. 166: 2317-22. PMID: 11160288
10. Edg2 receptor distribution in adult rat brain.  |  Handford, EJ., et al. 2001. Neuroreport. 12: 757-60. PMID: 11277579
11. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells.  |  Morales-Ruiz, M., et al. 2001. J Biol Chem. 276: 19672-7. PMID: 11278592
12. Expression of the endothelial cell differentiation gene 7 (EDG-7), a lysophosphatidic acid receptor, in ovarian tumor.  |  Nakamoto, T., et al. 2005. J Obstet Gynaecol Res. 31: 344-51. PMID: 16018784

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EDG-7 Antibody (C-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-EDG-7 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EDG-7 Antibody (C-7) Specifications

Alternate Product Name: EDG7

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 294-353

Epitope Target: EDG-7

Epitope Species: human

Product Reactivity/Detection: EDG-7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for EDG-7 Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin