Date published: 2026-4-26

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EDG-7 Inhibitors

The chemical class of EDG-7 inhibitors encompasses a diverse range of compounds that indirectly influence the function of LPAR3, primarily through modulation of its signaling pathways and ligand availability. These compounds achieve this by either antagonizing the LPAR3 receptor directly, altering the levels of its endogenous ligand, or by affecting downstream signaling cascades. This indirect approach is necessitated by the challenges inherent in targeting GPCRs like LPAR3 directly. Among these inhibitors, compounds like Ki16425, AM095, and Debio-0719 function by competitively binding to LPAR3, preventing the interaction with its natural ligand, lysophosphatidic acid. This inhibition can alter the receptor's downstream signaling, affecting various cellular responses mediated by LPAR3. Other compounds, such as MAFP, impact LPAR3 functionality indirectly by modulating the levels of lysophosphatidic acid in the cellular environment. Additionally, inhibitors targeting downstream signaling pathways of LPAR3, such as LY294002, Wortmannin, U0126, PD98059, and Rapamycin, play a crucial role in modulating the receptor's effects on cellular processes. These inhibitors affect key pathways like PI3K/Akt, MAPK/ERK, and mTOR, which are integral to the transduction of signals initiated by LPAR3 activation. The efficacy of these inhibitors in modulating LPAR3's function is determined by their ability to interact with these pathways and processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dodecylphosphate

2627-35-2sc-221566
sc-221566A
5 mg
25 mg
$152.00
$561.00
(0)

Dodecylphosphate, classified as an EDG-7, exhibits distinctive behavior as an acid halide, particularly through its capacity for self-assembly and micelle formation in solution. The long hydrophobic dodecyl chain enhances its surfactant properties, promoting unique molecular interactions at interfaces. Its reactivity is influenced by the phosphate group, which can engage in hydrogen bonding, affecting reaction kinetics and selectivity in various organic transformations.

Ki16425

355025-24-0sc-221788
sc-221788A
1 mg
5 mg
$199.00
$612.00
17
(1)

A selective LPA receptor antagonist, potentially inhibiting LPAR3 by blocking its binding sites.

Tetradecyl Phosphonate

4671-75-4sc-205519
sc-205519A
100 mg
500 mg
$24.00
$115.00
(0)

Tetradecyl Phosphonate, an EDG-7, showcases remarkable properties as an acid halide, particularly in its ability to form stable aggregates in polar solvents. The extended tetradecyl chain contributes to its amphiphilic nature, facilitating unique interactions with polar and nonpolar environments. Its phosphonate group enhances nucleophilicity, allowing for selective reactions with electrophiles, while also participating in complexation with metal ions, influencing catalytic pathways.

MAFP

188404-10-6sc-203440
5 mg
$219.00
4
(1)

An inhibitor of phospholipase A2, can indirectly affect LPAR3 signaling by altering LPA levels.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor, potentially influencing LPAR3-related signaling pathways.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Another PI3K inhibitor, could indirectly influence LPAR3 signaling.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

A MEK inhibitor, might impact pathways related to LPAR3 signaling.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

An inhibitor of MEK, potentially affecting LPAR3-related MAPK/ERK signaling.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor, could indirectly affect LPAR3-related signaling pathways.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

A ROCK inhibitor, can impact cytoskeletal dynamics potentially related to LPAR3 signaling.