ECE-1 Antibody (C-12): sc-376018
- ECE-1 Antibody (C-12) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 331-390 mapping within an extracellular domain of ECE-1 of human origin
- recommended for detection of ECE-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for ECE-1 Antibody (C-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with ECE-1 Antibody (C-12) (see ordering information below).
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ECE-1 Antibody (C-12) is a mouse monoclonal IgG2a antibody that detects endothelin-converting enzyme-1 (ECE-1) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ECE-1 plays a crucial role in converting big endothelin-1 to the biologically active peptide endothelin-1, which is a potent vasoconstrictor involved in regulating blood pressure and cardiovascular function. The importance of ECE-1 lies in modulating vascular tone and influencing various physiological processes, including cell proliferation and inflammation. ECE-1 is primarily located in the plasma membrane of endothelial cells, cardiomyocytes, and other tissues, where ECE-1 facilitates the cleavage of the trp21-val22 bond in its substrate. Multiple isoforms of ECE-1, generated from alternate promoters, allow for specific subcellular targeting due to their unique cytosolic tails, which can influence the localization and functional outcomes of endothelin signaling. Anti-ECE-1 antibody (C-12) is an essential tool for researchers studying cardiovascular diseases, endothelial function, and the intricate mechanisms of peptide signaling.
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ECE-1 Antibody (C-12) References:
- Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. | Yanagisawa, H., et al. 2000. J Clin Invest. 105: 1373-82. PMID: 10811845
- Polymorphisms in human endothelin-converting enzyme (ECE-1) promoter can modulate ECE-1 gene expression. | Gentile, MT. and Lembo, G. 2003. J Hypertens. 21: 2013-4. PMID: 14597841
- Genomic organisation of the mouse gene encoding endothelin-converting enzyme-1 (ECE-1) and mRNA expression of ECE-1 isoforms in murine tissues. | Lindenau, S., et al. 2006. Gene. 373: 109-15. PMID: 16540265
- On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer. | Smollich, M., et al. 2007. Breast Cancer Res Treat. 106: 361-9. PMID: 17295044
- In-silico characterization of ECE-1 inhibitors. | Ajay Babu, P., et al. 2012. Comput Biol Med. 42: 446-57. PMID: 22245098
- Association between ECE1 gene polymorphisms and risk of intracerebral haemorrhage. | Zeng, Y., et al. 2016. J Int Med Res. 44: 444-52. PMID: 27036146
- ECE-1 overexpression in head and neck cancer is associated with poor tumor differentiation and patient outcome. | Xu, ES., et al. 2019. Oral Dis. 25: 44-53. PMID: 29978582
- The -839(A/C) Polymorphism in the ECE1 Isoform b Promoter Associates With Osteoporosis and Fractures. | Hansen, KE., et al. 2019. J Endocr Soc. 3: 2041-2050. PMID: 31637345
- A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT). | Chen, L., et al. 2024. J Gene Med. 26: e3612. PMID: 37897251
- Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations. | Schweizer, A., et al. 1997. Biochem J. 328 (Pt 3): 871-7. PMID: 9396733
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ECE-1 Antibody (C-12) | sc-376018 | 200 µg/ml | $322.00 | |||
ECE-1 Antibody (C-12): m-IgG2a BP-HRP Bundle | sc-546056 | 200 µg Ab; 10 µg BP | $361.00 |