EBV EBNA-1 Antibody (3EB7): sc-81583

EBV EBNA-1 Antibody (3EB7) is a mouse monoclonal IgG1 antibody that detects EBV EBNA-1 in human samples by western blotting (WB) and immunoprecipitation (IP). EBV EBNA-1 is a crucial protein expressed in all Epstein-Barr virus-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, and plays a vital role in the synthesis and maintenance of the Epstein-Barr virus genome. EBV EBNA-1 is essential for the virus′s ability to transform human B cells, which is significant given its association with various malignancies. EBV EBNA-1 contains a unique glycine-alanine repeat that is important for its function in the viral life cycle, as this repeat aids in the replication and persistence of the viral genome within host cells. Additionally, EBV EBNA-1 interacts with cellular proteins to modulate host cell functions, further emphasizing its role in oncogenesis. Anti-EBV EBNA-1 antibody (3EB7) serves as an invaluable tool for researchers studying the mechanisms of EBV-related cancers and the biology of the virus itself, providing insights into potential therapeutic targets and strategies for intervention.

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EBV EBNA-1 Antibody (3EB7) References:

1. Functional domains of Epstein-Barr virus nuclear antigen EBNA-1.  |  Ambinder, RF., et al. 1991. J Virol. 65: 1466-78. PMID: 1847464
2. mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1.  |  Apcher, S., et al. 2009. J Virol. 83: 1289-98. PMID: 19019958
3. Detection of 12-o-tetradecanoylphorbol-13-acetate-induced cellular proteins that compete with the Epstein-Barr virus nuclear antigen 1 (EBNA-1) for binding to a site within the Epstein-Barr virus oriP.  |  Nonoyama, M., et al. 1990. Adv Exp Med Biol. 278: 125-36. PMID: 1963029
4. The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress.  |  Kamranvar, SA. and Masucci, MG. 2011. Leukemia. 25: 1017-25. PMID: 21394098
5. The V-val subtype Epstein-Barr virus nuclear antigen 1 promotes cell survival after serum withdrawal.  |  Chao, M., et al. 2015. Oncol Rep. 33: 958-66. PMID: 25434292
6. Antibodies specific for Epstein-Barr virus nuclear antigen-1 cross-react with human heterogeneous nuclear ribonucleoprotein L.  |  Lindsey, JW., et al. 2016. Mol Immunol. 69: 7-12. PMID: 26637929
7. EBNA1 antigen-specific CD8+ T cells in cerebrospinal fluid of patients with multiple sclerosis.  |  Erdur, H., et al. 2016. J Neuroimmunol. 294: 14-7. PMID: 27138093
8. EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.  |  Wilson, JB., et al. 2018. Cancers (Basel). 10: PMID: 29642420
9. The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization.  |  Wang, J., et al. 2020. Oncogene. 39: 603-616. PMID: 31511648
10. High Levels of Epstein-Barr Virus Nuclear Antigen-1-Specific Antibodies and Infectious Mononucleosis Act Both Independently and Synergistically to Increase Multiple Sclerosis Risk.  |  Hedström, AK., et al. 2019. Front Neurol. 10: 1368. PMID: 32038456

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.