EBV EBNA-1 Activators
EBV EBNA-1 Activators belong to a chemical class of compounds involved in the modulation of Epstein-Barr virus (EBV) and its associated protein, Epstein-Barr Nuclear Antigen 1 (EBNA-1). EBV is a herpesvirus that infects and establishes lifelong latency in human B lymphocytes. It is known to be associated with various diseases, including infectious mononucleosis and several types of lymphomas and carcinomas. EBNA-1 is one of the key viral proteins expressed during EBV infection and is essential for the replication and maintenance of the viral episome within host cells. It plays a crucial role in viral genome replication, transcriptional regulation, and immune evasion. Understanding the regulation of EBNA-1 and its interactions with host cellular components is essential for unraveling the biology of EBV.
The mechanism of action of EBV EBNA-1 Activators typically involves their interaction with EBNA-1, influencing its functions, protein-protein interactions, or its interactions with viral and host DNA. By modulating EBNA-1 activity, these activators impact the lifecycle of EBV, its ability to maintain latency within host cells, and its interactions with the host immune system. Research into EBV EBNA-1 Activators provides valuable insights into the complex interplay between viral proteins and host cellular machinery, shedding light on the molecular mechanisms underlying EBV infection and persistence within the human host.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, may alter histone acetylation, potentially affecting EBNA-1 expression by modulating chromatin structure and accessibility. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, a histone deacetylase inhibitor, might influence EBNA-1 expression through epigenetic modifications, altering chromatin dynamics. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, another histone deacetylase inhibitor, could impact EBNA-1 levels by changing the acetylation state of histones and thereby affecting gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, may induce EBNA-1 expression by altering DNA methylation patterns, thus affecting gene regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, could modulate EBNA-1 expression by interacting with retinoic acid receptors, influencing gene transcription. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate, a dihydrofolate reductase inhibitor, may affect EBNA-1 expression indirectly through its impact on nucleotide synthesis and DNA methylation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may influence EBNA-1 expression by modulating Wnt signaling pathway, which is known to play a role in gene expression regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, an activator of adenylate cyclase, could potentially alter EBNA-1 expression by influencing cyclic AMP levels and downstream signaling pathways. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea, primarily affecting DNA synthesis, might indirectly modify EBNA-1 expression by altering cell cycle dynamics. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin, a protein kinase C activator, may affect EBNA-1 expression through signaling pathways that influence cellular transcription factors. | ||||||