Prostratin CAS: 60857-08-1
MF: C22H30O6
MW: 390.47

Prostratin (CAS 60857-08-1)

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Noms alternatifs: Prostratin is also known as 12-Deoxyphorbol-13-Acetate.
Application: Prostratin is a PKC (Protein Kinase C) activator and potential HIV infection inhibitor that does not induce tumor formation.
Numéro CAS: 60857-08-1
Pureté: ≥98%
Masse Moléculaire: 390.47
Formule Moléculaire: C22H30O6
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
* Consulter le Certificat d'Analyses pour les données spécifiques à un lot (incluant la teneur en eau).

Prostratin is a Protein kinase C (PKC) activator that does not induce tumor formation. Prostratin upregulates latent HIV-1 provirus expression. Prostratin also inhibts HIV infection and viral spread at the entry/fusion step of viral life cycle. Prostratin essentially helps the body rid the latently infected CD4+ T-cells of the virus. Theoretically when used with other drugs (in vitro), Prostratin could eliminate the virus from latent and active life cycles completely. Prostratin is an activator of IKK. Prostratin was interestingly discovered from an ethnobotanical studies on Samoa. Prostratin was originally discovered in the tree Homolanthus nutans of which was known to be useful to scientific research on viruses.


Références

1. The structure of prostratin: A toxic tetracyclic diterpene ester from Pimelea prostrata.: A.R. Cashmore, et al.; Tetrahedron Lett. 20, 1737 (1976)
New tigliane and daphnane derivatives from Pimelea prostrata and Pimelea simplex: S. Zayed, et al.; Experientia 33, 1554 (1977)
2. Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin: Z. Szallasi, et al.; Cancer Res. 53, 2507 (1993)
3. Prostratin antagonizes HIV latency by activating NF-kappaB: S.A. Williams, et al.; J. Biol. Chem. 279, 42008 (2004)
4. Prostratin as a new therapeutic agent targeting HIV viral reservoirs: M. Hezareh; Drug News Perspect. 18, 496 (2005), (Review)
5.Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells: T. L. Sung & A. P. Rice; Retrovirology 3, 66 (2006)

État Physique :
Solid
Solubilité :
Soluble in DMSO (30 mg/ml), 100% ethanol (25 mg/ml), and DMF (~10 mg/ml).
STOCKAGE :
Store at -20° C
Point de fusion :
216-219° C
Point d'Ébullition :
550.50° C at 760 mmHg (Predicted)
Densité :
1.31 g/cm3 (Predicted)
Indice de Réfraction :
n20D 1.60 (Predicted)
IC50 :
Human immunodeficiency virus 1: EC5050 = 0.06 nM; Sindbis virus: EC5050 = >256 µM; Semliki forest virus: EC5050 = >256 µM; Ramos B cells: IC50 = 0.06 ug/ml (human); KB cells: IC50 = 1000 ug/ml (human)
Ki Data :
Protein kinase C α: Ki= 4.8 nM (Bos taurus); PKC: Ki= 190 nM (human)
Valeurs pK :
pKa: 11.4 (Predicted)
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
3
PubChem CID :
454217
Numéro MDL :
MFCD00674138

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Prostratin (CAS 60857-08-1)  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de Prostratin (CAS 60857-08-1). Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 10 sur un total de 21

PMID: # 30764849  Pérez-Fernández, A. et al. 2019. J. Exp. Clin. Cancer Res. 38: 80.

PMID: # 28368303  Jean, MJ. et al. 2017. Viruses. 9:

PMID: # 28819452  Chen, L. et al. 2017. Theranostics. 7: 2634-2648.

PMID: # 29170390  Fong, LE. et al. 2017. Sci Rep. 7: 16179.

PMID: # 28638377  Huang, H. et al. 2017. Front Microbiol. 8: 1035.

PMID: # 27529070  Chen, D. et al. 2016. Biomed Res Int. 2016: 5173205.

PMID: # 26728316  Chan, CN. et al. 2016. Retrovirology. 13: 1.

PMID: # 27731641  Tsai, JY. et al. 2016. J. Nat. Prod. 79: 2658-2666.

PMID: # 26151856  Nothias-Scaglia, LF. et al. 2015. Fitoterapia. 105: 202-9.

PMID: # 26590425  Wang, MT. et al. 2015. Cell. 163: 1237-51.

Citations 1 à 10 sur un total de 21
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