EBV EBNA-1 Antibody (1EB12): sc-81581

EBV EBNA-1 Antibody (1EB12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Epstein-Barr virus nuclear antigen 1 (EBNA-1) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Anti-EBNA-1 antibody (1EB12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. EBNA-1 plays a crucial role in the life cycle of the Epstein-Barr virus, as EBNA-1 is essential for the synthesis and maintenance of the viral genome, thereby facilitating viral persistence in host cells. EBNA-1 is expressed in all EBV-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, highlighting EBNA-1′s importance in oncogenesis. EBNA-1 interacts with other viral proteins, such as EBNA-2, which is vital for the transformation of B lymphocytes and the activation of specific gene transcription. EBNA-1′s presence in these tumors underscores EBNA-1′s potential as a target for therapeutic interventions and diagnostic applications in EBV-related malignancies.

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EBV EBNA-1 Antibody (1EB12) References:

1. Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma.  |  Ruf, IK., et al. 1999. Mol Cell Biol. 19: 1651-60. PMID: 10022853
2. Epstein-Barr virus nuclear antigen-1 (EBNA-1) associated oligoclonal bands in patients with multiple sclerosis.  |  Rand, KH., et al. 2000. J Neurol Sci. 173: 32-9. PMID: 10675577
3. Replication of a chimeric origin containing elements from Epstein-Barr virus ori P and bovine papillomavirus minimal origin.  |  Kivimäe, S., et al. 2001. Virus Res. 75: 1-11. PMID: 11311423
4. Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2.  |  Lin, J., et al. 2002. J Virol. 76: 232-42. PMID: 11739688
5. Epstein-Barr virus gene expression in nasopharyngeal carcinoma.  |  Young, LS., et al. 1988. J Gen Virol. 69 (Pt 5): 1051-65. PMID: 2836550
6. Transient Gene Expression in Suspension HEK293-EBNA1 Cells.  |  L'Abbé, D., et al. 2018. Methods Mol Biol. 1850: 1-16. PMID: 30242676
7. Alzheimer's disease risk associated with changes in Epstein-Barr virus nuclear antigen 1-specific epitope targeting antibody levels.  |  Sim, KY., et al. 2024. J Infect Public Health. 17: 102462. PMID: 38824738
8. Enhanced and cross-reactive in vitro memory B cell response against Epstein-Barr virus nuclear antigen 1 in multiple sclerosis.  |  Marti, Z., et al. 2024. Front Immunol. 15: 1334720. PMID: 39257578
9. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.  |  Tong, X., et al. 1995. Mol Cell Biol. 15: 4735-44. PMID: 7651391
10. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein.  |  Nonkwelo, C., et al. 1996. J Virol. 70: 623-7. PMID: 8523583
11. Novel hypotheses for the roles of EBNA-1 and BHRF1 in EBV-related cancers.  |  Horner, D., et al. 1995. Intervirology. 38: 195-205. PMID: 8682617
12. Multiple functions within the Epstein-Barr virus EBNA-3A protein.  |  Cludts, I. and Farrell, PJ. 1998. J Virol. 72: 1862-9. PMID: 9499037

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EBV EBNA-1 Antibody (1EB12) has 30 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EBV EBNA-1 Antibody (1EB12) Specifications

Alternate Product Name: EBV EBNA-1

Product Clone Name: 1EB12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 40-65

Epitope Target: EBV EBNA-1

Epitope Species: EBV

Product Reactivity/Detection: Epstein-Barr virus nuclear antigen 1

Species Reactivity/Detection:

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 30 citations in various scientific publications

Available Conjugates/Forms for EBV EBNA-1 Antibody (1EB12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin