EBV EBNA-1 Antibody (3EB16): sc-81587

EBV EBNA-1 Antibody (3EB16) is a mouse monoclonal IgG1 antibody that detects the Epstein-Barr virus nuclear antigen 1 protein (EBV EBNA-1) of human species reactivity by western blotting (WB) and immunoprecipitation (IP). EBV EBNA-1 plays a crucial role in the life cycle of the Epstein-Barr virus, as EBV EBNA-1 is essential for the synthesis and maintenance of the viral genome, thereby facilitating the virus′s persistence in host cells. EBV EBNA-1 is expressed in all EBV-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, highlighting its importance in oncogenesis. EBV EBNA-1′s ability to bind to the viral genome ensures that the virus can replicate and persist within the host, which is critical for the development of EBV-related malignancies. Additionally, EBV EBNA-1 interacts with various cellular proteins, influencing cellular pathways that promote cell survival and proliferation, further underscoring its significance in both viral pathogenesis and cancer biology. With robust performance in applications such as western blotting (WB) and immunoprecipitation (IP), anti-EBV EBNA-1 antibody (3EB16) is an invaluable tool for researchers studying the mechanisms of EBV infection and its associated diseases.

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EBV EBNA-1 Antibody (3EB16) References:

1. Epstein-Barr virus nuclear antigen 1 evades direct immune recognition by CD4+ T helper cells.  |  Mautner, J., et al. 2004. Eur J Immunol. 34: 2500-9. PMID: 15307182
2. The epstein-Barr-virus-encoded membrane protein LMP but not the nuclear antigen EBNA-1 induces rejection of transfected murine mammary carcinoma cells.  |  Trivedi, P., et al. 1991. Int J Cancer. 48: 794-800. PMID: 1649140
3. Epstein-Barr virus nuclear antigen 1 replication and segregation functions in nasopharyngeal carcinoma cell lines.  |  Sivachandran, N., et al. 2011. J Virol. 85: 10425-30. PMID: 21795327
4. Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: stimulation by Cdc6 through its direct interaction with EBNA1.  |  Moriyama, K., et al. 2012. J Biol Chem. 287: 23977-94. PMID: 22589552
5. Small molecule and peptide-mediated inhibition of Epstein-Barr virus nuclear antigen 1 dimerization.  |  Kim, SY., et al. 2012. Biochem Biophys Res Commun. 424: 251-6. PMID: 22735264
6. Variations of Epstein-Barr virus nuclear antigen 1 in Epstein-Barr virus-associated gastric carcinomas from Guangzhou, southern China.  |  Chen, JN., et al. 2012. PLoS One. 7: e50084. PMID: 23189182
7. Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.  |  Deschamps, T., et al. 2017. J Gen Virol. 98: 251-265. PMID: 28284242
8. Reactivation of Epstein-Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function.  |  Jiang, L., et al. 2019. Proc Natl Acad Sci U S A. 116: 26614-26624. PMID: 31822610
9. Antibodies from Multiple Sclerosis Brain Identified Epstein-Barr Virus Nuclear Antigen 1 & 2 Epitopes which Are Recognized by Oligoclonal Bands.  |  Wang, Z., et al. 2021. J Neuroimmune Pharmacol. 16: 567-580. PMID: 32808238
10. Low sun exposure acts synergistically with high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels in multiple sclerosis etiology.  |  Hedström, AK., et al. 2021. Eur J Neurol. 28: 4146-4152. PMID: 34435414

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.