EBV EBNA-1 Antibody (3EB13): sc-81586

EBV EBNA-1 Antibody (3EB13) is a mouse monoclonal IgG1 antibody that detects EBV EBNA-1 in human samples by western blotting (WB) and immunoprecipitation (IP). EBV EBNA-1 is a crucial protein expressed in all Epstein-Barr virus-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, and plays a vital role in the synthesis and maintenance of the Epstein-Barr virus genome. EBV EBNA-1 is essential for the transformation of human B cells, facilitating viral replication and contributing to the oncogenic potential of the virus. Notably, EBV EBNA-1 is involved in the regulation of viral latency and reactivation, making anti-EBV EBNA-1 antibody (3EB13) a key tool for understanding the mechanisms of EBV-related malignancies. EBV EBNA-1′s ability to interact with various cellular factors enhances its role in modulating host cell functions, which is critical for viral survival and proliferation. Using EBV EBNA-1 (3EB13) antibody, researchers can gain insights into the molecular pathways influenced by EBV EBNA-1, furthering our understanding of viral pathogenesis and cancer biology.

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EBV EBNA-1 Antibody (3EB13) References:

1. Epstein-Barr virus nuclear antigen-1-dependent and -independent oriP-binding cellular proteins.  |  Kusano, S., et al. 2001. Intervirology. 44: 283-90. PMID: 11684889
2. Epstein-Barr virus nuclear antigen-1 colocalizes with lamin B1 in the nucleoplasm and along the nuclear rim.  |  Ito, S., et al. 2003. Arch Virol. 148: 1633-42. PMID: 12898336
3. Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes.  |  Dresang, LR., et al. 2009. J Virol. 83: 2930-40. PMID: 19129441
4. Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.  |  Sivachandran, N., et al. 2010. J Virol. 84: 11113-23. PMID: 20719947
5. Diagnostic significance of combined detection of Epstein-Barr virus antibodies, VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA for nasopharyngeal carcinoma.  |  Cai, YL., et al. 2014. Asian Pac J Cancer Prev. 15: 2001-6. PMID: 24716925
6. Minicircle-oriP-miR-31 as a Novel EBNA1-Specific miRNA Therapy Approach for Nasopharyngeal Carcinoma.  |  Wu, J., et al. 2017. Hum Gene Ther. 28: 415-427. PMID: 28042945
7. Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.  |  Dheekollu, J., et al. 2017. Oncotarget. 8: 7248-7264. PMID: 28077791
8. EBNA-1, the major nuclear antigen of Epstein-Barr virus, resembles 'RGG' RNA binding proteins.  |  Snudden, DK., et al. 1994. EMBO J. 13: 4840-7. PMID: 7957053
9. bcl-2, Epstein-Barr virus-latent membrane protein, EBNA-1, and EBNA-2 staining in posttransplantation lymphoproliferative disorders.  |  Chetty, R., et al. 1996. Blood. 87: 5395. PMID: 8652861
10. Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2.  |  Fischer, N., et al. 1997. J Biol Chem. 272: 3999-4005. PMID: 9020106

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.