EBV EBNA-1 Antibody (1EB2): sc-81579

EBV EBNA-1 Antibody (1EB2) is a mouse monoclonal IgG1 antibody that detects EBV EBNA-1 in human samples by western blotting (WB) and immunoprecipitation (IP). EBV EBNA-1 is a crucial protein expressed in all Epstein-Barr virus-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, and plays a vital role in the synthesis and maintenance of the Epstein-Barr virus genome. EBV EBNA-1 is essential for the virus′s ability to transform human B cells, which is significant given its association with various malignancies. The structure of EBV EBNA-1 is characterized by a unique C-terminal domain that facilitates binding to the viral genome, ensuring stability and replication of the virus within host cells. Understanding EBV EBNA-1 structure provides insights into how the virus manipulates host cellular mechanisms to promote survival and proliferation, ultimately contributing to the pathogenesis of EBV-related cancers. Anti-EBV EBNA-1 antibody (1EB2) serves as an invaluable tool for researchers studying the molecular mechanisms of EBV and its role in oncogenesis, enabling the exploration of potential therapeutic targets and strategies.

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EBV EBNA-1 Antibody (1EB2) References:

1. Assessment of Epstein-Barr virus (EBV) serostatus by enzyme immunoassays: plausibility of the isolated EBNA-1 IgG positive serological profile.  |  García, T., et al. 2008. J Infect. 57: 351-3. PMID: 18789535
2. EBNA1 and host factors in Epstein-Barr virus latent DNA replication.  |  Frappier, L. 2012. Curr Opin Virol. 2: 733-9. PMID: 23031715
3. Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival.  |  Frappier, L. 2012. Viruses. 4: 1537-1547. PMID: 23170171
4. Potential cellular functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus.  |  Westhoff Smith, D. and Sugden, B. 2013. Viruses. 5: 226-40. PMID: 23325328
5. EBNA1, EBNA2, and EBNA3 link Epstein-Barr virus and hypovitaminosis D in multiple sclerosis pathogenesis.  |  Marcucci, SB. and Obeidat, AZ. 2020. J Neuroimmunol. 339: 577116. PMID: 31805475
6. Impact of genetic variation on the molecular mimicry between Anoctamin-2 and Epstein-Barr virus nuclear antigen 1 in Multiple Sclerosis.  |  Sepúlveda, N. 2021. Immunol Lett. 238: 29-31. PMID: 34310987
7. Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.  |  Lanz, TV., et al. 2022. Nature. 603: 321-327. PMID: 35073561
8. Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats.  |  Li, JSZ., et al. 2023. Nature. 616: 504-509. PMID: 37046091
9. Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.  |  Thomas, OG., et al. 2023. Sci Adv. 9: eadg3032. PMID: 37196088
10. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein.  |  Nonkwelo, C., et al. 1996. J Virol. 70: 623-7. PMID: 8523583

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.