E3BP Antibody (E-12): sc-377159

E3BP Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects E3BP in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). E3BP, also known as PDHX (Pyruvate dehydrogenase protein X component), is a crucial 501 amino acid mitochondrial protein that plays a vital role in the proper functioning of the pyruvate dehydrogenase (PDH) complex, which serves as the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the conversion of pyruvate into acetyl-CoA. E3BP functions as an anchor for the E3 component to the E2 core of the PDH complex, a critical interaction necessary for maintaining the integrity and functionality of the entire enzyme complex. Disruptions in the gene encoding E3BP can lead to E3BP deficiency, which presents symptoms similar to those of PDH deficiency and Leigh syndrome, including lactic acidosis, developmental delays, seizures, and other neurological impairments. Anti-E3BP antibody (E-12) is an essential tool for researchers studying metabolic disorders and mitochondrial function, providing insights into the molecular mechanisms underlying these conditions.

The preferred E3BP antibody is E3BP Antibody (H-6): sc-377255.