E2F-5 Antibody (MH-5): sc-968
- E2F-5 Antibody (MH-5) is a mouse monoclonal IgG1 κ, cited in 25 publications, provided at 200 µg/ml
- epitope mapping between amino acids 89-346 of E2F-5 of human origin
- recommended for detection of E2F-5 of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2F-5 Antibody (MH-5) for WB applications. These reagents are now offered in bundles with E2F-5 Antibody (MH-5) (see ordering information below).
E2F-5 Antibody (MH-5) is a mouse monoclonal IgG1 antibody that detects E2F-5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). E2F-5 plays a crucial role in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase, by forming heterodimers with the DP-1 protein to create an active E2F transcriptional regulatory complex. This complex is essential for the transcriptional activation of genes that are vital for cell proliferation and DNA synthesis. Proper functioning of E2F-5 is important because dysregulation can lead to uncontrolled cell growth, a hallmark of cancer. E2F-5 is part of a larger family of E2F transcription factors, which includes E2F-1, E2F-2, E2F-3, E2F-4, E2F-6, and E2F-7, each contributing to the intricate network of cell cycle regulation. E2F-5 (MH-5) monoclonal antibody is a valuable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying tumorigenesis.
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E2F-5 Antibody (MH-5) References:
- Overexpression of E2F-5 correlates with a pathological basal phenotype and a worse clinical outcome. | Umemura, S., et al. 2009. Br J Cancer. 100: 764-71. PMID: 19259095
- A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. | Jiang, Y., et al. 2011. World J Gastroenterol. 17: 470-7. PMID: 21274376
- E2f4 and E2f5 are essential for the development of the male reproductive system. | Danielian, PS., et al. 2016. Cell Cycle. 15: 250-60. PMID: 26825228
- MYCN-induced E2F5 promotes neuroblastoma cell proliferation through regulating cell cycle progression. | Liu, Y., et al. 2019. Biochem Biophys Res Commun. 511: 35-40. PMID: 30765227
- E2F5 promotes prostate cancer cell migration and invasion through regulation of TFPI2, MMP-2 and MMP-9. | Karmakar, D., et al. 2020. Carcinogenesis. 41: 1767-1780. PMID: 32386317
- Knockdown of E2F5 induces cell death via the TP53‑dependent pathway in breast cancer cells carrying wild‑type TP53. | Inagaki, Y., et al. 2020. Oncol Rep. 44: 2241-2252. PMID: 33000282
- E2F5 promotes proliferation and invasion of gastric cancer through directly upregulating UBE2T transcription. | Li, L., et al. 2022. Dig Liver Dis. 54: 937-945. PMID: 34583905
- Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell carcinoma proliferation by destabilizing E2F5 transcript. | Wang, Z., et al. 2024. Aging (Albany NY). 16: 1897-1910. PMID: 38271139
- Molecular and functional characterisation of E2F-5, a new member of the E2F family. | Buck, V., et al. 1995. Oncogene. 11: 31-8. PMID: 7542760
- The molecular and functional characterization of E2F-5 transcription factor. | Vaishnav, YN., et al. 1998. Biochem Biophys Res Commun. 242: 586-92. PMID: 9464260
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-5 Antibody (MH-5) | sc-968 | 200 µg/ml | $316.00 | |||
E2F-5 Antibody (MH-5): m-IgG Fc BP-HRP Bundle | sc-536545 | 200 µg Ab; 10 µg BP | $354.00 | |||
E2F-5 Antibody (MH-5): m-IgGκ BP-HRP Bundle | sc-533696 | 200 µg Ab; 40 µg BP | $354.00 | |||
E2F-5 Antibody (MH-5): m-IgG1 BP-HRP Bundle | sc-544667 | 200 µg Ab; 20 µg BP | $354.00 |