E2F-3 Antibody (D-2): sc-28308

E2F-3 Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects E2F-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). E2F-3 plays a crucial role in regulating the cell cycle, particularly in the transition from the G1 phase to the S phase, where DNA replication occurs. This regulation is vital for proper cell proliferation and differentiation, as dysregulation of E2F-3 can lead to uncontrolled cell growth and is often implicated in various cancers. E2F-3 is primarily located in the nucleus, where E2F-3 binds to specific DNA sequences to activate the transcription of genes necessary for cell cycle progression. Understanding E2F-3 localization is important because nuclear presence is essential for function as a transcription factor, and any aberrations in localization can disrupt normal cell cycle regulation. E2F-3 interacts with other members of the E2F family and forms heterodimers with the DP-1 protein, which enhances transcriptional activity. anti-E2F-3 antibody (D-2) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying tumorigenesis.

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E2F-3 Antibody (D-2) References:

1. Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region.  |  He, Y., et al. 2000. Oncogene. 19: 3422-33. PMID: 10918599
2. MiRNAs and E2F3: a complex network of reciprocal regulations in human cancers.  |  Gao, Y., et al. 2017. Oncotarget. 8: 60624-60639. PMID: 28947999
3. HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3).  |  Santerre, M., et al. 2019. J Biol Chem. 294: 3618-3633. PMID: 30591585
4. Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3.  |  Zhao, W., et al. 2020. J Cell Biochem. 121: 3516-3525. PMID: 32065448
5. Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation.  |  Cao, X., et al. 2022. Ann N Y Acad Sci. 1507: 84-98. PMID: 34468993
6. Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis.  |  Wu, X., et al. 2021. Bioengineered. 12: 9046-9057. PMID: 34657558
7. Prognostic analysis of E2F transcription factors E2F1 and E2F3 in four independent pediatric neuroblastoma cohorts.  |  Wang, H., et al. 2022. BMC Pediatr. 22: 376. PMID: 35764946
8. A novel circ_0000654/miR-375/E2F3 ceRNA network in esophageal squamous cell carcinoma.  |  Luo, C., et al. 2022. Thorac Cancer. 13: 2223-2234. PMID: 35790503
9. Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state.  |  Yang, X., et al. 2022. Theranostics. 12: 6865-6882. PMID: 36276637
10. E2F3 induces DNA damage repair, stem-like properties and therapy resistance in breast cancer.  |  Wei, L., et al. 2023. Biochim Biophys Acta Mol Basis Dis. 1869: 166816. PMID: 37499929

The preferred E2F-3 antibody is E2F-3 Antibody (PG30): sc-56665.