Dyrk2 Antibody (949C2E): sc-517662
- Dyrk2 Antibody (949C2E) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a KLH-coupled peptide corresponding to amino acids 105-135 of DYRK2 of human origin
- recommended for detection of DYRK2 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dyrk2 Antibody (949C2E). This work is in progress.
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Dyrk2 Antibody (949C2E) is a mouse monoclonal IgG1 antibody that detects Dyrk2 protein of human origin by western blotting (WB). Dyrk2, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a crucial role in various cellular processes, including neurogenesis, by regulating the phosphorylation of target proteins. Dyrk2 is primarily located in the nucleus and cytoplasm, where Dyrk2 is involved in critical signaling pathways that influence cell differentiation and proliferation. Proper localization of Dyrk2 is essential for function, as this positioning ensures interaction with substrates and regulatory proteins effectively. Dysregulation of Dyrk2 has been implicated in several neurodevelopmental disorders, highlighting Dyrk2′s importance in maintaining normal cellular function. Additionally, Dyrk2 exists in two isoforms in human fetal brain tissue, which may have distinct roles in development and cellular signaling. The genes encoding Dyrk2 and related family members are located on human chromosomes 12 and 1q32, respectively, further emphasizing the complexity and significance of Dyrk2 in human biology.
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Dyrk2 Antibody (949C2E) References:
- Dyrk2 involved in regulating LPS-induced neuronal apoptosis. | Sun, Y., et al. 2017. Int J Biol Macromol. 104: 979-986. PMID: 28676338
- Impairment of DYRK2 by DNMT1‑mediated transcription augments carcinogenesis in human colorectal cancer. | Kumamoto, T., et al. 2020. Int J Oncol. 56: 1529-1539. PMID: 32236621
- Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases. | Correa-Sáez, A., et al. 2020. Cell Mol Life Sci. 77: 4747-4763. PMID: 32462403
- A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival. | Lara-Chica, M., et al. 2022. Cell Death Differ. 29: 105-117. PMID: 34363019
- Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. | Yogosawa, S., et al. 2021. Commun Biol. 4: 1204. PMID: 34671097
- Kinase DYRK2 acts as a regulator of autophagy and an indicator of favorable prognosis in gastric carcinoma. | Zhang, X., et al. 2022. Colloids Surf B Biointerfaces. 209: 112182. PMID: 34749023
- DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage. | Kawamura, A., et al. 2022. J Cell Sci. 135: PMID: 35582972
- DYRK2 downregulation in colorectal cancer leads to epithelial-mesenchymal transition induction and chemoresistance. | Wu, C., et al. 2022. Sci Rep. 12: 22496. PMID: 36577753
- Dual inhibition of HSF1 and DYRK2 impedes cancer progression. | Tandon, V., et al. 2023. Biosci Rep. 43: PMID: 36622366
- Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase. | Yoshida, S., et al. 2024. Proc Natl Acad Sci U S A. 121: e2320070121. PMID: 38968120
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dyrk2 Antibody (949C2E) | sc-517662 | 100 µg/ml | $322.00 |