Dyrk1A Antibody (RR.7): sc-100376

Dyrk1A Antibody (RR.7) is a mouse monoclonal IgG2b kappa light chain antibody that detects Dyrk1A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Dyrk1A antibody (RR.7) is available as a non-conjugated format. Dyrk1A, also known as Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A, plays a crucial role in various cellular processes, particularly in regulating cell proliferation and differentiation. Dyrk1A (RR.7) antibody targets a dual-specificity kinase that phosphorylates both serine/threonine and tyrosine residues, essential for modulating signaling pathways that influence cell growth and development. Dyrk1A is predominantly localized in the nucleus and highly expressed in tissues such as testis, muscle, and developing nervous system, highlighting importance in neurogenesis and other developmental processes. Dyrk1A monoclonal antibody (RR.7) recognizes a protein implicated in learning and memory functions, with research suggesting that alterations in activity may contribute to cognitive deficits associated with Down syndrome. Four isoforms of Dyrk1A, resulting from alternative splicing, further underscore complexity of regulatory mechanisms and functional diversity within cellular contexts.

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Dyrk1A Antibody (RR.7) References:

1. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.  |  Guimera, J., et al. 1999. Genomics. 57: 407-18. PMID: 10329007
2. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.  |  Kimura, R., et al. 2007. Hum Mol Genet. 16: 15-23. PMID: 17135279
3. DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.  |  Alvarez, M., et al. 2007. Mol Biol Cell. 18: 1167-78. PMID: 17229891
4. Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro.  |  Adayev, T., et al. 2007. Biochemistry. 46: 7614-24. PMID: 17536841
5. DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.  |  Ryoo, SR., et al. 2007. J Biol Chem. 282: 34850-7. PMID: 17906291
6. DYRK1A inhibitors for disease therapy: Current status and perspectives.  |  Liu, T., et al. 2022. Eur J Med Chem. 229: 114062. PMID: 34954592
7. Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction.  |  Lan, C., et al. 2022. EBioMedicine. 82: 104139. PMID: 35810562
8. Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases.  |  Yang, Y., et al. 2023. Biochem Pharmacol. 212: 115521. PMID: 36990324
9. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.  |  Kentrup, H., et al. 1996. J Biol Chem. 271: 3488-95. PMID: 8631952
10. Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.  |  Shindoh, N., et al. 1996. Biochem Biophys Res Commun. 225: 92-9. PMID: 8769099
11. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.  |  Song, WJ., et al. 1996. Genomics. 38: 331-9. PMID: 8975710
12. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.  |  Becker, W., et al. 1998. J Biol Chem. 273: 25893-902. PMID: 9748265

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dyrk1A Antibody (RR.7) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Dyrk1A Antibody (RR.7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dyrk1A Antibody (RR.7) Specifications

Alternate Product Name: DYRK1A

Product Clone Name: RR.7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 674-763

Epitope Target: Dyrk1A

Epitope Species: human

Product Reactivity/Detection: Dyrk1A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Dyrk1A Antibody (RR.7): N/A