Dynactin 6 Antibody (A-2): sc-398678

Dynactin 6 Antibody (A-2) is a mouse monoclonal IgG2a antibody that detects Dynactin 6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dynactin 6, also known as Protein WS-3, is a crucial component of the pointed-end-binding subcomplex of the Dynactin shoulder complex, which plays a vital role in facilitating the binding of the Dynein microtubule motor to its cargo. This interaction is essential for various cellular processes, including organelle transport, mitosis, and the maintenance of cellular architecture. Dynactin 6 is ubiquitously expressed across all tissues, indicating fundamental importance in cellular function and organ health. Notably, Dynactin 6 interacts with other key proteins such as Dynactin 5 and Dynactin p62, which together regulate the dynamics of Dynactin-membranous cargo interactions, thereby influencing the efficiency of Dynein-driven transport mechanisms. Dynactin 6′s ability to modulate these interactions underscores significance in maintaining cellular homeostasis and responding to physiological demands.

The preferred Dynactin 6 antibody is Dynactin 6 Antibody (B-6): sc-398694.