DTX3L Antibody (D-10): sc-514776
- DTX3L Antibody (D-10) is a mouse monoclonal IgG2a κ DTX3L antibody provided at 200 µg/ml
- raised against amino acids 41-340 mapping near the N-terminus of DTX3L of human cytomegalovirus origin
- DTX3L Antibody (D-10) is recommended for detection of DTX3L of human origin by WB, IP, IF and ELISA
- Anti-DTX3L Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DTX3L Antibody (D-10) for WB applications. These reagents are now offered in bundles with DTX3L Antibody (D-10) (see ordering information below).
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SEE ALSO...
DTX3L Antibody (D-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects DTX3L protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DTX3L (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DTX3L, also known as BBAP, is a 740 amino acid protein that plays a crucial role in the ubiquitination pathway, functioning as an E3 ubiquitin ligase. DTX3L features a basic N-terminus, a central proline-rich region, and a C-terminal RING-type zinc finger domain, which is essential for binding two zinc ions and facilitating interactions with other proteins involved in ubiquitination. This structural motif allows DTX3L to heterodimerize with Deltex-1, enhancing the E3 ubiquitin ligase complex′s activity and amplifying the regulation of Notch signaling, a critical pathway in cell differentiation and development. DTX3L′s ability to modulate transcription through interactions with specific transcription factors underscores its importance in cellular processes and potential implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DTX3L Antibody (D-10) References:
- Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. | Yamamoto, N., et al. 2001. J Biol Chem. 276: 45031-40. PMID: 11564735
- Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. | Izon, DJ., et al. 2002. Immunity. 16: 231-43. PMID: 11869684
- The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. | Takeyama, K., et al. 2003. J Biol Chem. 278: 21930-7. PMID: 12670957
- NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. | Cui, XY., et al. 2004. J Biol Chem. 279: 25858-65. PMID: 15082708
- BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. | Juszczynski, P., et al. 2006. Mol Cell Biol. 26: 5348-59. PMID: 16809771
- Human deltex is a conserved regulator of Notch signalling. | Matsuno, K., et al. 1998. Nat Genet. 19: 74-8. PMID: 9590294
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DTX3L Antibody (D-10) | sc-514776 | 200 µg/ml | $316.00 | |||
DTX3L Antibody (D-10): m-IgG Fc BP-HRP Bundle | sc-531219 | 200 µg Ab; 10 µg BP | $354.00 | |||
DTX3L Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-524842 | 200 µg Ab, 40 µg BP | $354.00 | |||
DTX3L Antibody (D-10): m-IgG2a BP-HRP Bundle | sc-547730 | 200 µg Ab; 10 µg BP | $354.00 | |||
DTX3L Antibody (D-10) AC | sc-514776 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DTX3L Antibody (D-10) HRP | sc-514776 HRP | 200 µg/ml | $316.00 | |||
DTX3L Antibody (D-10) FITC | sc-514776 FITC | 200 µg/ml | $330.00 | |||
DTX3L Antibody (D-10) PE | sc-514776 PE | 200 µg/ml | $343.00 | |||
DTX3L Antibody (D-10) Alexa Fluor® 488 | sc-514776 AF488 | 200 µg/ml | $357.00 | |||
DTX3L Antibody (D-10) Alexa Fluor® 546 | sc-514776 AF546 | 200 µg/ml | $357.00 | |||
DTX3L Antibody (D-10) Alexa Fluor® 594 | sc-514776 AF594 | 200 µg/ml | $357.00 | |||
DTX3L Antibody (D-10) Alexa Fluor® 647 | sc-514776 AF647 | 200 µg/ml | $357.00 | |||
DTX3L Antibody (D-10) Alexa Fluor® 680 | sc-514776 AF680 | 200 µg/ml | $357.00 | |||
DTX3L Antibody (D-10) Alexa Fluor® 790 | sc-514776 AF790 | 200 µg/ml | $357.00 |