dsg4 Antibody (6E7): sc-517109

dsg4 Antibody (6E7) is a mouse monoclonal IgG1 kappa light chain antibody that detects dsg4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-dsg4 antibody (6E7) is available as a non-conjugated format. Desmoglein 4 (dsg4) is a crucial type I membrane protein belonging to the cadherin family, which plays a significant role in cell adhesion, particularly in the hair follicle, where dsg4 mediates keratinocyte adhesion and is essential for the transition from cell proliferation to differentiation. This function is vital for maintaining the integrity of the epidermis and ensuring proper hair follicle development. dsg4 protein is expressed in various tissues, including the salivary gland, suprabasal epidermis, hair follicle, testis, prostate, and skin, highlighting dsg4′s importance in both structural and functional aspects of these tissues. The human DSG4 gene, located on chromosome 18q12, consists of 16 exons and spans approximately 37 kb, positioned between the DSG1 and DSG3 genes, which further emphasizes dsg4′s role within the desmoglein family. With dsg4′s ability to facilitate critical cellular interactions, dsg4 monoclonal antibody (6E7) serves as an essential tool for researchers studying cell adhesion mechanisms and related pathologies.

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dsg4 Antibody (6E7) References:

1. Genetic evidence for a novel human desmosomal cadherin, desmoglein 4.  |  Whittock, NV. and Bower, C. 2003. J Invest Dermatol. 120: 523-30. PMID: 12648213
2. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.  |  Kljuic, A., et al. 2003. Cell. 113: 249-60. PMID: 12705872
3. Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.  |  Whittock, NV. 2003. J Invest Dermatol. 120: 970-80. PMID: 12787123
4. Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.  |  Nagasaka, T., et al. 2004. J Clin Invest. 114: 1484-92. PMID: 15545999
5. A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model.  |  Meyer, B., et al. 2004. Differentiation. 72: 541-7. PMID: 15617564
6. Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle.  |  Bazzi, H., et al. 2006. Differentiation. 74: 129-40. PMID: 16533311
7. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation.  |  Bazzi, H., et al. 2009. Differentiation. 78: 292-300. PMID: 19683850
8. Autoimmune and infectious skin diseases that target desmogleins.  |  Amagai, M. 2010. Proc Jpn Acad Ser B Phys Biol Sci. 86: 524-37. PMID: 20467217
9. Expression patterns of the mouse Spir-2 actin nucleator.  |  Pleiser, S., et al. 2010. Gene Expr Patterns. 10: 345-50. PMID: 20723621
10. A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein 4 (DSG4) gene.  |  Farooq, M., et al. 2011. Br J Dermatol. 165: 425-31. PMID: 21495994
11. A novel deletion mutation in the DSG4 gene underlies autosomal recessive hypotrichosis with variable phenotype in two unrelated consanguineous families.  |  Ullah, A., et al. 2015. Clin Exp Dermatol. 40: 78-84. PMID: 25251037
12. Novel D323G mutation of DSG4 gene in a girl with localized autosomal recessive hypotrichosis clinically overlapped with monilethrix.  |  Wang, JM., et al. 2015. Int J Dermatol. 54: 1163-8. PMID: 26173648

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-dsg4 Antibody (6E7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-dsg4 Antibody (6E7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

dsg4 Antibody (6E7) Specifications

Alternate Product Name: dsg4

Product Clone Name: 6E7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 531-630

Epitope Target: dsg4

Epitope Species: human

Product Reactivity/Detection: dsg4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for dsg4 Antibody (6E7): N/A