dsg3 Antibody (3G133): sc-59776

dsg3 Antibody (3G133) is a mouse monoclonal IgG1 antibody that detects desmoglein 3 (DSG3) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. DSG3 is a crucial type I membrane protein that plays a vital role in cell adhesion, particularly within desmosomes, which are specialized cell junctions that provide structural integrity to tissues. DSG3 monoclonal antibody (3G133) is essential for maintaining the cohesion of keratinocytes in the epidermis, and DSG3 dysfunction is implicated in autoimmune conditions such as pemphigus vulgaris, where autoantibodies target DSG3, leading to blistering and skin fragility. Notably, DSG3 is part of the cadherin family and interacts with other desmogleins, such as desmoglein 1 and desmoglein 2, to form a robust adhesive network that is critical for tissue architecture. Abnormal expression of DSG3 has been observed in various carcinoma cell lines, suggesting that DSG3 regulation may be linked to tumor progression and metastasis, highlighting DSG3′s importance not only in normal physiology but also in pathological conditions. Anti-DSG3 antibody (3G133) is therefore an invaluable tool for researchers investigating DSG3′s roles in both health and disease.

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dsg3 Antibody (3G133) References:

1. The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18.  |  Arnemann, J., et al. 1992. Hum Genet. 89: 347-50. PMID: 1601426
2. Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients.  |  Nielsen, K., et al. 2005. Cornea. 24: 661-8. PMID: 16015083
3. DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis.  |  Chen, YJ., et al. 2007. Oncogene. 26: 467-76. PMID: 16878157
4. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays.  |  Patel, V., et al. 2013. Oral Oncol. 49: 93-101. PMID: 23010602
5. Increased expression of microRNA-338-3p contributes to production of Dsg3 antibody in pemphigus vulgaris patients.  |  Liu, Q., et al. 2018. Mol Med Rep. 18: 550-556. PMID: 29749496
6. Homozygous deletion of the DSG3 terminal exon associated with acantholytic blistering of the oral and laryngeal mucosa.  |  Jiang, N., et al. 2024. Am J Med Genet A. 194: 389-393. PMID: 37850634
7. Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment.  |  Roh, JY. and Stanley, JR. 1995. J Invest Dermatol. 104: 720-4. PMID: 7738346
8. cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen.  |  Ishikawa, H., et al. 1994. Mamm Genome. 5: 803-4. PMID: 7894164
9. The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12.  |  Wang, Y., et al. 1994. Genomics. 20: 492-5. PMID: 8034325
10. Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the Triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cells.  |  Aoyama, Y. and Kitajima, Y. 1999. J Invest Dermatol. 112: 67-71. PMID: 9886266

The preferred dsg3 antibody is dsg3 Antibody (5H10): sc-23912.