DRG1 Antibody (E-2): sc-390030

DRG1 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects DRG1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DRG1 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DRG1, also known as developmentally regulated GTP binding protein 1 or NEDD3, consists of 367 amino acids and is primarily localized in the cytoplasm, where DRG1 plays a crucial role in cellular processes such as proliferation, differentiation, and apoptosis. DRG1 is particularly important as DRG1 is involved in the regulation of cell growth and survival, which has implications in tumor formation and metastasis. DRG1 interacts with specific proteins like TAL1 and TAL2, which are transcription factors that influence hematopoiesis and other developmental processes. The gene encoding DRG1 is located on human chromosome 22, a region associated with various genetic disorders, including Phelan-McDermid syndrome and neurofibromatosis type 2. Notably, DRG1 undergoes post-translational modifications such as polyubiquitination and sumoylation, with polyubiquitination leading to proteolytic degradation, thereby regulating DRG1 levels and activity within the cell.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DRG1 Antibody (E-2) References:

1. DRG represents a family of two closely related GTP-binding proteins.  |  Li, B. and Trueb, B. 2000. Biochim Biophys Acta. 1491: 196-204. PMID: 10760581
2. The Drg-1 gene suppresses tumor metastasis in prostate cancer.  |  Bandyopadhyay, S., et al. 2003. Cancer Res. 63: 1731-6. PMID: 12702552
3. Expression of DRG during murine embryonic development.  |  Sazuka, T., et al. 1992. Biochem Biophys Res Commun. 189: 371-7. PMID: 1280421
4. DRG: a novel developmentally regulated GTP-binding protein.  |  Sazuka, T., et al. 1992. Biochem Biophys Res Commun. 189: 363-70. PMID: 1449490
5. Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression.  |  Bandyopadhyay, S., et al. 2004. Oncogene. 23: 5675-81. PMID: 15184886
6. The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating transcription factor 3 in prostate cancer.  |  Bandyopadhyay, S., et al. 2006. Cancer Res. 66: 11983-90. PMID: 17178897
7. A common variant in DRD3 receptor is associated with autism spectrum disorder.  |  de Krom, M., et al. 2009. Biol Psychiatry. 65: 625-30. PMID: 19058789
8. A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts.  |  Schenker, T., et al. 1994. J Biol Chem. 269: 25447-53. PMID: 7929244
9. Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins.  |  Mahajan, MA., et al. 1996. Oncogene. 12: 2343-50. PMID: 8649774

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DRG1 Antibody (E-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DRG1 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DRG1 Antibody (E-2) Specifications

Alternate Product Name: DRG1

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 138-239

Epitope Target: DRG1

Epitope Species: human

Product Reactivity/Detection: DRG1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DRG1 Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin