DR6 Antibody (E-4): sc-376873

DR6 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects DR6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-DR6 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DR6, also known as TNFRSF21, is a member of the tumor necrosis factor receptor superfamily and plays a crucial role in mediating apoptosis and inflammatory responses. DR6 (E-4) antibody recognizes proteins primarily located on the cell surface, where DR6 interacts with TRAIL ligand to initiate apoptotic signaling pathways. This interaction is vital for regulating cell death and maintaining tissue homeostasis, as dysregulation of DR6 signaling can lead to various diseases, including cancer and autoimmune disorders. A death domain in DR6 is essential for function, allowing signal transduction of apoptotic signals effectively. Understanding DR6′s role in cellular processes provides insights into function and highlights potential therapeutic targeting in diseases characterized by aberrant apoptosis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DR6 Antibody (E-4) References:

1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.  |  Yu, KY., et al. 1999. J Biol Chem. 274: 13733-6. PMID: 10318773
2. MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1.  |  Pan, X., et al. 2021. Cancer Cell Int. 21: 161. PMID: 33750398
3. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
4. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
5. A novel domain within the 55 kd TNF receptor signals cell death.  |  Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
6. A death-domain-containing receptor that mediates apoptosis.  |  Kitson, J., et al. 1996. Nature. 384: 372-5. PMID: 8934525
7. The receptor for the cytotoxic ligand TRAIL.  |  Pan, G., et al. 1997. Science. 276: 111-3. PMID: 9082980
8. An antagonist decoy receptor and a death domain-containing receptor for TRAIL.  |  Pan, G., et al. 1997. Science. 277: 815-8. PMID: 9242610
9. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.  |  Sheridan, JP., et al. 1997. Science. 277: 818-21. PMID: 9242611
10. A novel receptor for Apo2L/TRAIL contains a truncated death domain.  |  Marsters, SA., et al. 1997. Curr Biol. 7: 1003-6. PMID: 9382840
11. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling.  |  Pan, G., et al. 1998. FEBS Lett. 424: 41-5. PMID: 9537512
12. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.  |  Pan, G., et al. 1998. FEBS Lett. 431: 351-6. PMID: 9714541

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DR6 Antibody (E-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DR6 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DR6 Antibody (E-4) Specifications

Alternate Product Name: DR6

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 71-220

Epitope Target: DR6

Epitope Species: human

Product Reactivity/Detection: DR6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DR6 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin