DP2 Antibody (C-5): sc-271898

DP2 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects DP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). DP2 Antibody (C-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DP2, also known as Prostaglandin D2 receptor 2 or CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), is a G protein-coupled receptor that plays a pivotal role in mediating prostaglandin D2 (PGD2) effects in numerous physiological and pathological processes. DP2 is primarily located on specific white blood cells, such as Th2 cells, eosinophils, and basophils, which are crucial for regulating allergic and inflammatory responses. PGD2 activation of DP2 triggers signaling events that enhance Th2 cell chemotaxis, promoting Th2-type immune responses characterized by IL-4, IL-5, and IL-13 cytokine secretion. DP2′s involvement in asthma, allergic rhinitis, and atopic dermatitis pathogenesis underscores its importance as a therapeutic target for managing allergic and inflammatory diseases. Anti-DP2 antibody (C-5) serves as an essential tool for researchers investigating these critical biological processes, given DP2′s intricate role in immune regulation and inflammation.

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DP2 Antibody (C-5) References:

1. Discovery of three novel orphan G-protein-coupled receptors.  |  Marchese, A., et al. 1999. Genomics. 56: 12-21. PMID: 10036181
2. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease.  |  Cosmi, L., et al. 2000. Eur J Immunol. 30: 2972-9. PMID: 11069080
3. Chemoattractant receptors expressed on type 2 T cells and their role in disease.  |  Cosmi, L., et al. 2001. Int Arch Allergy Immunol. 125: 273-9. PMID: 11574748
4. Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide.  |  Annunziato, F., et al. 2001. J Allergy Clin Immunol. 108: 815-21. PMID: 11692110
5. CRTH2: marker for the detection of human Th2 and Tc2 cells.  |  Cosmi, L., et al. 2001. Adv Exp Med Biol. 495: 25-9. PMID: 11774575
6. Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner.  |  Michimata, T., et al. 2002. Mol Hum Reprod. 8: 181-7. PMID: 11818521
7. The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock.  |  Venet, F., et al. 2004. Clin Immunol. 113: 278-84. PMID: 15507393
8. The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses.  |  Pettipher, R. 2008. Br J Pharmacol. 153 Suppl 1: S191-9. PMID: 17965752
9. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.  |  Crosignani, S., et al. 2008. J Med Chem. 51: 2227-43. PMID: 18318469
10. PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.  |  Werder, RB., et al. 2018. Sci Transl Med. 10: PMID: 29743346
11. Distinct CRTH2+CD161+ (peTh2) memory CD4+ T-cell cytokine profiles in food allergy and eosinophilic gastrointestinal disorders.  |  Makiya, MA., et al. 2023. Clin Exp Allergy. 53: 1031-1040. PMID: 37487654
12. Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.  |  Ullah, MA., et al. 2024. Nat Commun. 15: 10253. PMID: 39592603

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DP2 Antibody (C-5) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-DP2 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DP2 Antibody (C-5) Specifications

Alternate Product Name: DP2

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 11-39

Epitope Target: DP2

Epitope Species: mouse

Product Reactivity/Detection: DP2 of human origin, CRTH2 of mouse origin and the corresponding rat homolog

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for DP2 Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin