DP-1 Antibody (2Q471): sc-70990
- DP-1 Antibody (2Q471) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against full length DP-1 of human origin
- recommended for detection of DP-1 of mouse, rat and human origin by WB, IP and IF
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DP-1 Antibody (2Q471) for WB applications. These reagents are now offered in bundles with DP-1 Antibody (2Q471) (see ordering information below).
DP-1 Antibody (2Q471) is a mouse monoclonal IgG2b antibody that detects DP-1 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. DP-1, a crucial component of the E2F transcriptional regulatory complex, plays a significant role in cell cycle regulation by forming heterodimers with E2F-1, thereby facilitating the transcriptional activation of genes essential for the G1 and S phases of the cell cycle. The interaction between DP-1 and E2F-1 is vital for proper cell cycle progression, ensuring timely expression of genes that drive cell proliferation and division. Dysregulation of this complex can lead to uncontrolled cell growth, contributing to tumorigenesis. DP-1′s ability to bind with E2F-1 and other E2F family members, including E2F-2, E2F-3, E2F-4, and E2F-5, underscores DP-1′s importance in maintaining cellular homeostasis and responding to developmental cues. Anti-DP-1 antibody (2Q471) serves as an invaluable tool for researchers studying cell cycle dynamics and molecular mechanisms underlying cancer progression.
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DP-1 Antibody (2Q471) References:
- Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex. | Hofland, K., et al. 2000. Clin Cancer Res. 6: 1488-97. PMID: 10778981
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. | Hsu, SI., et al. 2001. EMBO J. 20: 2273-85. PMID: 11331592
- Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. | Chan, JA., et al. 2002. Appl Immunohistochem Mol Morphol. 10: 322-6. PMID: 12607600
- SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell cycle progression via interaction with DP-1. | Masuhiro, Y., et al. 2008. J Biol Chem. 283: 31575-83. PMID: 18687693
- Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1. | Sabri, M., et al. 2011. J Bacteriol. 193: 551-62. PMID: 21097633
- Adenovirus E1A directly targets the E2F/DP-1 complex. | Pelka, P., et al. 2011. J Virol. 85: 8841-51. PMID: 21715488
- Protectin DX promotes the inflammatory resolution via activating COX-2/L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome. | Hu, X., et al. 2022. Int Immunopharmacol. 102: 108348. PMID: 34920958
- Structural Analyses of DP-1, a Protein with the Ability To Bind Gold Nanoparticles, by Using Nuclear Magnetic Resonance Spectroscopy. | Futagawa, K., et al. 2024. Chembiochem. 25: e202300554. PMID: 37792876
- DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein. | Bandara, LR., et al. 1994. EMBO J. 13: 3104-14. PMID: 8039504
- Association with E2F-1 governs intracellular trafficking and polyubiquitination of DP-1. | Magae, J., et al. 1999. Oncogene. 18: 593-605. PMID: 9989809
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DP-1 Antibody (2Q471) | sc-70990 | 200 µg/ml | $316.00 | |||
DP-1 Antibody (2Q471): m-IgGκ BP-HRP Bundle | sc-534406 | 200 µg Ab; 40 µg BP | $354.00 | |||
DP-1 Antibody (2Q471): m-IgG2b BP-HRP Bundle | sc-549252 | 200 µg Ab; 10 µg BP | $354.00 |