Dnmt2 Antibody (A-7): sc-271513
- Dnmt2 Antibody (A-7) is a mouse monoclonal IgG2b κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 121-391 of Dnmt2 of human origin
- recommended for detection of Dnmt2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Dnmt2 Antibody (A-7) for WB applications. This reagent is now offered in a bundle with Dnmt2 Antibody (A-7) (see ordering information below).
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Dnmt2 Antibody (A-7) is a mouse monoclonal IgG2b antibody that detects Dnmt2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dnmt2 plays a crucial role in the regulation of gene expression by mediating DNA methylation, particularly in newly integrated retroviral DNA, which is essential for maintaining genomic stability and preventing the activation of potentially harmful viral sequences. Unlike Dnmt1, which is primarily involved in maintaining methylation patterns during DNA replication, anti-Dnmt2 antibody (A-7) targets a protein expressed at lower levels in adult tissues and lacks the large N-terminal regulatory domain found in Dnmt1. This unique structural feature of Dnmt2 suggests a specialized function in the context of retroviral integration, highlighting Dnmt2′s importance in the cellular response to viral infections and the overall epigenetic landscape. Dnmt2 (A-7) antibody serves as an invaluable tool for researchers investigating the dynamics of DNA methylation and its implications in various biological processes and diseases.
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Dnmt2 Antibody (A-7) References:
- The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis. | Tuorto, F., et al. 2015. EMBO J. 34: 2350-62. PMID: 26271101
- Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation. | Jeltsch, A., et al. 2017. RNA Biol. 14: 1108-1123. PMID: 27232191
- Cross-Talk between Dnmt2-Dependent tRNA Methylation and Queuosine Modification. | Ehrenhofer-Murray, AE. 2017. Biomolecules. 7: PMID: 28208632
- Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. | Zhang, Y., et al. 2018. Nat Cell Biol. 20: 535-540. PMID: 29695786
- Dnmt2-null sperm block maternal transmission of a paramutant phenotype†. | Yu, T., et al. 2021. Biol Reprod. 105: 603-612. PMID: 33929014
- The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. | Bloniarz, D., et al. 2021. Aging (Albany NY). 13: 15833-15874. PMID: 34139673
- DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis. | Adamczyk-Grochala, J., et al. 2023. Apoptosis. 28: 166-185. PMID: 36273376
- Restricted tRNA methylation by intermolecular disulfide bonds in DNMT2/TRDMT1. | Li, H., et al. 2023. Int J Biol Macromol. 251: 126310. PMID: 37579906
- Determinants of DNMT2/TRDMT1 preference for substrates tRNA and DNA during the evolution. | Li, H., et al. 2023. RNA Biol. 20: 875-892. PMID: 37966982
- Biological function molecular pathways and druggability of DNMT2/TRDMT1. | Li, H., et al. 2024. Pharmacol Res. 205: 107222. PMID: 38782147
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dnmt2 Antibody (A-7) | sc-271513 | 200 µg/ml | $316.00 | |||
Dnmt2 Antibody (A-7): m-IgG2b BP-HRP Bundle | sc-548541 | 200 µg Ab; 10 µg BP | $354.00 |