DnaJC3 Antibody (A-7): sc-393559
- DnaJC3 Antibody (A-7) is a mouse monoclonal IgG1 κ DnaJC3 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of DnaJC3 of human origin
- DnaJC3 Antibody (A-7) is recommended for detection of DnaJC3 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-DnaJC3 Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DnaJC3 Antibody (A-7) for WB and IHC(P) applications. These reagents are now offered in bundles with DnaJC3 Antibody (A-7) (see ordering information below).
DnaJC3 Antibody (A-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects DnaJC3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-DnaJC3 antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DnaJC3, also known as P58, HP58, PRKRI, or P58IPK, plays a crucial role in cellular stress responses as an interferon-induced, double-stranded RNA-activated protein kinase inhibitor. DnaJC3 is primarily located in the cytoplasm, where DnaJC3 interacts with various signaling pathways to modulate the activity of other proteins involved in stress responses and apoptosis. DnaJC3 localization is significant because DnaJC3 allows for rapid responses to cellular stress, ensuring that cells can adapt to changing environments and maintain homeostasis. Through protein kinase inhibition, DnaJC3 helps regulate the phosphorylation state of target proteins, which is essential for controlling cell survival and death. DnaJC3′s ability to modulate these pathways highlights DnaJC3′s importance in various physiological processes and potential implications in diseases where stress response mechanisms are disrupted.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DnaJC3 Antibody (A-7) References:
- Analysis of the function of mycobacterial DnaJ proteins by overexpression and microarray profiling. | Stewart, GR., et al. 2004. Tuberculosis (Edinb). 84: 180-7. PMID: 15207487
- The C-terminal (331-376) sequence of Escherichia coli DnaJ is essential for dimerization and chaperone activity: a small angle X-ray scattering study in solution. | Shi, YY., et al. 2005. J Biol Chem. 280: 22761-8. PMID: 15849180
- DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. | Robichon, C., et al. 2006. Biochim Biophys Acta. 1761: 1107-13. PMID: 16950652
- The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. | Genevaux, P., et al. 2007. Mol Microbiol. 66: 840-57. PMID: 17919282
- DnaJ recruits DnaK to protein aggregates. | Acebrón, SP., et al. 2008. J Biol Chem. 283: 1381-1390. PMID: 17984091
- Organization and expression of the dnaJ and dnaK genes of Escherichia coli K12. | Saito, H. and Uchida, H. 1978. Mol Gen Genet. 164: 1-8. PMID: 360036
- Identification of the E. coli dnaJ gene product. | Georgopoulos, CP., et al. 1980. Mol Gen Genet. 178: 583-8. PMID: 6446654
- Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli. | Tomoyasu, T., et al. 1998. Mol Microbiol. 30: 567-81. PMID: 9822822
- Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ. | Suh, WC., et al. 1998. Proc Natl Acad Sci U S A. 95: 15223-8. PMID: 9860950
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DnaJC3 Antibody (A-7) | sc-393559 | 200 µg/ml | $316.00 | |||
DnaJC3 Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-530497 | 200 µg Ab; 10 µg BP | $354.00 | |||
DnaJC3 Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-523998 | 200 µg Ab, 40 µg BP | $354.00 | |||
DnaJC3 Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-544089 | 200 µg Ab; 20 µg BP | $354.00 | |||
DnaJC3 Antibody (A-7) AC | sc-393559 AC | 500 µg/ml, 25% agarose | $416.00 | |||
DnaJC3 Antibody (A-7) HRP | sc-393559 HRP | 200 µg/ml | $316.00 | |||
DnaJC3 Antibody (A-7) FITC | sc-393559 FITC | 200 µg/ml | $330.00 | |||
DnaJC3 Antibody (A-7) PE | sc-393559 PE | 200 µg/ml | $343.00 | |||
DnaJC3 Antibody (A-7) Alexa Fluor® 488 | sc-393559 AF488 | 200 µg/ml | $357.00 | |||
DnaJC3 Antibody (A-7) Alexa Fluor® 546 | sc-393559 AF546 | 200 µg/ml | $357.00 | |||
DnaJC3 Antibody (A-7) Alexa Fluor® 594 | sc-393559 AF594 | 200 µg/ml | $357.00 | |||
DnaJC3 Antibody (A-7) Alexa Fluor® 647 | sc-393559 AF647 | 200 µg/ml | $357.00 | |||
DnaJC3 Antibody (A-7) Alexa Fluor® 680 | sc-393559 AF680 | 200 µg/ml | $357.00 | |||
DnaJC3 Antibody (A-7) Alexa Fluor® 790 | sc-393559 AF790 | 200 µg/ml | $357.00 |