DnaJC3 Activators
DnaJC3 activators are a class of chemical compounds that target and modulate the activity of the DnaJC3 protein, also known as P58IPK within the cellular environment. DnaJC3 is a multifunctional protein that plays a crucial role in regulating cellular stress responses and protein homeostasis. It is primarily located in the endoplasmic reticulum (ER), a cellular organelle involved in the synthesis and folding of proteins. DnaJC3 is notable for its dual functions, acting both as a chaperone protein, assisting in protein folding and assembly, a key component of the cellular stress response.
DnaJC3 activators are designed to enhance the chaperone function of DnaJC3, thereby promoting proper protein folding and preventing protein misfolding and aggregation. This class of compounds can help maintain protein homeostasis within the ER, which is essential for normal cellular function. By supporting the chaperone activity of DnaJC3, these activators can alleviate ER stress, which is implicated in various diseases, including neurodegenerative disorders and metabolic syndromes. Understanding the mechanisms underlying DnaJC3 activation holds promise for developing novel strategies to address protein misfolding diseases and enhance cellular proteostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an ER stress inducer that inhibits N-linked glycosylation, leading to protein misfolding and potential DnaJC3 activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the SERCA pump, disrupting ER calcium homeostasis, causing ER stress, and potentially increasing DnaJC3 expression. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts ER-to-Golgi transport, perturbing ER homeostasis and potentially activating the UPR, including DnaJC3 induction. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-PBA is a chemical chaperone that alleviates ER stress, indirectly reducing DnaJC3 activation by promoting proper protein folding. | ||||||
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $246.00 | ||
Guanabenz is an alpha-2 adrenergic receptor agonist that may activate DnaJC3 through cellular stress response pathways. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin inhibits Hsp90, indirectly affecting protein folding in the ER, potentially leading to changes in ER stress and DnaJC3 activation. | ||||||
L-Azetidine-2-carboxylic acid | 2133-34-8 | sc-263441 sc-263441A | 1 g 5 g | $139.00 $421.00 | 1 | |
AZC is a proline analogue that induces ER stress, potentially activating the UPR and increasing DnaJC3 expression due to misfolded proteins. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Fenretinide is a synthetic retinoid that may influence ER stress levels, with effects on DnaJC3 not well-documented but possibly related to stress signaling. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Vitamin C is an antioxidant that may reduce oxidative stress and indirectly contribute to ER stress reduction without directly activating DnaJC3. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Sodium 4-phenylbutyrate is a salt form of 4-PBA, a chemical chaperone that indirectly modulates DnaJC3 activity by promoting proper protein folding and reducing ER stress. | ||||||