Dmc1 Antibody (3C134): sc-70965
- Dmc1 Antibody (3C134) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant His-tagged full length human Dmc1
- recommended for detection of Dmc1 of mouse, rat and human origin by WB and IP
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Dmc1 Antibody (3C134) for WB applications. These reagents are now offered in bundles with Dmc1 Antibody (3C134) (see ordering information below).
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Dmc1 Antibody (3C134) is a mouse monoclonal IgG1 antibody that detects Dmc1 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Dmc1 plays a crucial role in meiotic recombination, a process essential for accurate chromosome segregation during gamete formation. Dmc1 (3C134) antibody specifically recognizes nuclear localization, where Dmc1 facilitates genetic material exchange between homologous chromosomes, ensuring genetic diversity and stability. Nuclear localization of Dmc1 remains critical for nucleoprotein filament formation necessary for homologous pairing and strand invasion during meiosis. Mutations or dysregulation of Dmc1 can lead to infertility and chromosomal abnormalities, highlighting Dmc1′s significance in reproductive biology and genetic integrity. Anti-Dmc1 antibody (3C134) serves as an invaluable tool for researchers studying meiotic recombination mechanisms and genetic disorder implications.
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Dmc1 Antibody (3C134) References:
- Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). | Dray, E., et al. 2011. Proc Natl Acad Sci U S A. 108: 3560-5. PMID: 21307306
- Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing. | Kobayashi, W., et al. 2016. Sci Rep. 6: 24228. PMID: 27052786
- SYCP3 regulates strand invasion activities of RAD51 and DMC1. | Kobayashi, W., et al. 2017. Genes Cells. 22: 799-809. PMID: 28745000
- DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing. | He, WB., et al. 2018. J Med Genet. 55: 198-204. PMID: 29331980
- RPA resolves conflicting activities of accessory proteins during reconstitution of Dmc1-mediated meiotic recombination. | Chan, YL., et al. 2019. Nucleic Acids Res. 47: 747-761. PMID: 30462332
- Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase. | Slotman, JA., et al. 2020. PLoS Genet. 16: e1008595. PMID: 32502153
- The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates. | Hinch, AG., et al. 2020. Mol Cell. 79: 689-701.e10. PMID: 32610038
- Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. | Xu, J., et al. 2021. Nucleic Acids Res. 49: 13135-13149. PMID: 34871438
- MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1. | Sun, D., et al. 2022. Anticancer Drugs. 33: 701-709. PMID: 35946537
- The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination. | Altmannova, V., et al. 2022. iScience. 25: 105439. PMID: 36388968
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dmc1 Antibody (3C134) | sc-70965 | 200 µg/ml | $322.00 | |||
Dmc1 Antibody (3C134): m-IgG Fc BP-HRP Bundle | sc-539324 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dmc1 Antibody (3C134): m-IgG1 BP-HRP Bundle | sc-541409 | 200 µg Ab; 20 µg BP | $361.00 |