DLK2 Antibody (D-5): sc-514089

DLK2 Antibody (D-5) is a mouse monoclonal IgG3 antibody that detects DLK2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DLK2, also known as Epidermal Growth Factor-Like Protein 9 (EGFL9), is a 383 amino acid single-pass transmembrane protein characterized by six tandem EGF-like repeats in its extracellular domain, which is a hallmark of the EGF-like protein family. DLK2 plays a crucial role in regulating adipogenesis, particularly in 3T3-L1 preadipocytes and mesenchymal C3H10T1/2 cells, where DLK2 functions in opposition to its closely related counterpart, DLK. The interplay between DLK and DLK2 is significant, as their expression levels are inversely correlated; thus, alterations in the expression of one can lead to compensatory changes in the other, highlighting the importance of their coordinated regulation in adipocyte differentiation. Additionally, DLK2 exists in two isoforms due to alternative splicing, which may further influence its functional roles in cellular processes. Anti-DLK2 antibody (D-5) is an essential tool for researchers investigating the complex mechanisms of adipogenesis and the functional dynamics of EGF-like proteins.

The preferred DLK2 antibody is DLK2 Antibody (B-10): sc-376896.