DLD Antibody (D-8): sc-271569

DLD Antibody (D-8) is a mouse monoclonal IgG2a antibody that detects DLD (Dihydrolipoyl dehydrogenase) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). DLD plays a crucial role in cellular energy metabolism as a flavin-dependent oxidoreductase, functioning as a key component of several important enzyme complexes, including the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes. DLD is primarily located in the mitochondrial matrix, where DLD exists in various oligomeric forms such as monomers, homodimers, or tetramers, which are essential for enzymatic activity. DLD′s ability to generate NADH and lipoic acid from dihydrolipoic acid and NAD+ is vital for maintaining the redox balance within the mitochondria, thereby supporting ATP production and overall cellular function. Importantly, mutations in the DLD gene can lead to severe metabolic disorders, such as maple syrup urine disease and congenital infantile lactic acidosis, highlighting DLD′s significance in human health. DLD (D-8) antibody is an invaluable tool for researchers studying mitochondrial function and related metabolic pathways.

The preferred DLD antibody is DLD Antibody (G-2): sc-365977.