Dim1 Antibody (B-9): sc-390839
- Dim1 Antibody (B-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-142 representing full length Dim1 of human origin
- recommended for detection of Dim1 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Dim1 Antibody (B-9) for WB applications. This reagent is now offered in a bundle with Dim1 Antibody (B-9) (see ordering information below).
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Dim1 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects Dim1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dim1, also known as TXNL4A (Thioredoxin-like protein 4A) or Spliceosomal U5 snRNP-specific 15 kDa protein, is a crucial 142 amino acid protein involved in pre-mRNA splicing, which is essential for proper gene expression. Dim1′s importance is underscored by its role in the cell cycle; deletion of the gene encoding Dim1 in Schizosaccharomyces pombe results in embryonal lethality during gastrulation due to failure to express early zygotic transcripts. Additionally, Dim1′s sensitivity to the microtubule destabilizing drug thiabendazole suggests involvement in mitotic spindle formation, highlighting a critical function in G2/M progression and chromosomal segregation during mitosis. Localized in the nucleus, Dim1 interacts with several proteins, including heterogeneous nuclear ribonucleoprotein F (hnRNP F), hnRNP H2, Cas-L, and PQBP-1, to regulate gene expression, further emphasizing significance in cellular processes. anti-Dim1 antibody (B-9) is an invaluable tool for researchers studying the intricate mechanisms of gene regulation and cell cycle dynamics.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dim1 Antibody (B-9) | sc-390839 | 200 µg/ml | $316.00 | |||
Dim1 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-540864 | 200 µg Ab; 10 µg BP | $354.00 |