Dim1 Inhibitors
Chemical inhibitors of Dim1 can interfere with its function by targeting cellular processes and pathways that are integral to its role in ribosome assembly and cell cycle progression. Paclitaxel (Taxol), for instance, stabilizes microtubules, which can arrest the cell cycle and indirectly inhibit Dim1 by preventing its participation in ribosome biogenesis during cell cycle-dependent processes. Similarly, Mitomycin C, by crosslinking DNA, activates a cascade of DNA damage responses that can result in cell cycle arrest, thereby inhibiting Dim1's associated functions. Camptothecin and Etoposide, which target topoisomerase I and II respectively, induce DNA damage and subsequent cell cycle arrest, again indirectly impeding Dim1's role in the cell cycle and ribosome assembly. Bleomycin, through oxidative DNA damage, can lead to apoptosis and cell cycle arrest, creating a cellular condition that diminishes Dim1's functional relevance.
Moreover, inhibitors like Cycloheximide, which disrupts protein synthesis, lessen the cellular demand for ribosomes, thereby reducing the need for Dim1's activity in ribosome assembly. Actinomycin D inhibits RNA synthesis, which is essential for the processing of pre-ribosomal RNA-a process in which Dim1 is a key player-thus indirectly inhibiting its function. Proteasome inhibitor Bortezomib causes an accumulation of cell cycle regulatory proteins, leading to an arrest that can affect Dim1's activities. Rocaglamide and Homoharringtonine disrupt translation by interacting with components of the translation initiation machinery and by preventing translation elongation, respectively. These actions result in a decreased requirement for ribosome assembly, indirectly inhibiting the function of Dim1. Similarly, Puromycin and Anisomycin inhibit protein synthesis by causing premature chain termination and blocking peptide bond formation, which in turn disrupts the processes that rely on the proper function of Dim1.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and thereby inhibits their disassembly, leading to cell cycle arrest. Since Dim1 is implicated in cell cycle regulation and ribosome biogenesis, stabilized microtubules can disrupt cell cycle progression and ribosome assembly, indirectly inhibiting Dim1 function by preventing it from contributing to these processes. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C functions as a DNA crosslinker, which activates DNA damage responses and can lead to cell cycle arrest. Dim1, involved in cell cycle checkpoints, would be functionally inhibited as the cell cycle is arrested, preventing its role in ribosome assembly during the cell cycle. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor which causes a buildup of topoisomerase I-DNA cleavable complexes and induces DNA damage. By activating DNA damage response pathways that arrest the cell cycle, the cellular context in which Dim1 operates is altered, indirectly inhibiting its function in ribosome assembly and cell cycle progression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, leading to DNA strand breaks and triggering DNA damage response. Dim1, associated with ribosome biogenesis and cell cycle control, would be indirectly inhibited due to cell cycle arrest and alteration of the ribosome assembly process. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Bleomycin causes DNA strand breaks via oxidative damage, leading to cell cycle arrest and apoptosis. Indirectly, this halts the cell cycle-dependent processes in which Dim1 is involved, thus inhibiting its function related to ribosome biogenesis within the cell cycle. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation. As Dim1 is involved in ribosome assembly, this inhibition of protein synthesis indirectly impacts Dim1 function by affecting the cellular demand and utilization of ribosomes, reducing the functional need for Dim1 activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA at the transcription initiation complex and prevents elongation of RNA by RNA polymerase. By inhibiting RNA synthesis, it indirectly inhibits Dim1 function as Dim1 is involved in processing pre-ribosomal RNA, a critical step in ribosome biogenesis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor and can lead to cell cycle arrest due to the accumulation of regulatory proteins. This alteration of the cell cycle can indirectly inhibit the function of Dim1, which is implicated in the cell cycle and ribosome biogenesis. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits translation initiation by binding to eIF4A, an RNA helicase involved in the initiation of mRNA translation. As Dim1 is important for ribosome biogenesis, indirectly, rocaglamide can inhibit Dim1 function by reducing the need for ribosome assembly as general mRNA translation is impeded. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin causes premature chain termination during protein synthesis by acting as an analog of aminoacyl-tRNA. This disrupts protein synthesis, and indirectly, the role of Dim1 in ribosome assembly is inhibited as the demand for functional ribosomes in the cell is compromised. | ||||||