Dicer Antibody (A-2): sc-136981

Dicer Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dicer in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Dicer antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dicer plays a crucial role in the RNA interference pathway, where Dicer (A-2) is responsible for processing precursor microRNAs and short hairpin RNAs into functional small interfering RNAs. This function is vital for regulating gene expression and maintaining cellular homeostasis, as Dicer helps to silence unwanted or harmful RNA molecules, thereby preventing potential disruptions in cellular processes. Dicer (A-2) monoclonal antibody is predominantly localized in the cytoplasm of mammalian cells, where Dicer co-localizes with calreticulin in the endoplasmic reticulum, highlighting its importance in RNA processing and cellular signaling. The gene encoding human Dicer is located on chromosome 14q31, and Dicer expression is observed in various tissues, including the brain, heart, liver, lung, pancreas, kidney, and placenta. Notably, Dicer′s cleavage activity is ATP-independent, although ATP may facilitate the release of products necessary for the enzyme′s rapid turnover. Additionally, immunoprecipitation studies have shown that Dicer forms a complex with the PIWI domain of eIF2C translation initiation factors, further underscoring its integral role in RNA metabolism and gene regulation.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dicer Antibody (A-2) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-Dicer Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dicer Antibody (A-2) Specifications

Alternate Product Name: DICER1

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1701-1912

Epitope Target: Dicer

Epitope Species: human

Product Reactivity/Detection: Dicer

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Dicer Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Dicer antibody is Dicer Antibody (F-10): sc-136979.