DHTKD1 Antibody (F-11): sc-398620
- DHTKD1 Antibody (F-11) is a mouse monoclonal IgG2b κ DHTKD1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 598-637 within an internal region of DHTKD1 of human origin
- DHTKD1 Antibody (F-11) is recommended for detection of DHTKD1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DHTKD1 Antibody (F-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DHTKD1 Antibody (F-11) for WB applications. These reagents are now offered in bundles with DHTKD1 Antibody (F-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
DHTKD1 Antibody (F-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects DHTKD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DHTKD1 (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DHTKD1 protein, also known as probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial, plays a crucial role in cellular metabolism as a component of the 2-oxoglutarate dehydrogenase complex, which is essential for the conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide. This enzymatic process is vital for the tricarboxylic acid cycle, linking carbohydrate and fat metabolism, and is critical for energy production in cells. DHTKD1 is a 919 amino acid protein that belongs to the alpha-ketoglutarate dehydrogenase family and requires thiamine pyrophosphate as a cofactor for activity. Localized in the mitochondrion, DHTKD1 is encoded by a gene that maps to human chromosome 10p14 and mouse chromosome 2 A1, highlighting evolutionary conservation and importance across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DHTKD1 Antibody (F-11) References:
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Nagase, T., et al. 2000. DNA Res. 7: 273-81. PMID: 10997877
- DOOR syndrome: deficiency of E1 component of the 2-oxoglutarate dehydrogenase complex. | Surendran, S., et al. 2002. Am J Med Genet. 113: 371-4. PMID: 12457410
- Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components. | Hiromasa, Y., et al. 2004. J Biol Chem. 279: 6921-33. PMID: 14638692
- Distinct modes of recognition of the lipoyl domain as substrate by the E1 and E3 components of the pyruvate dehydrogenase multienzyme complex. | Fries, M., et al. 2007. J Mol Biol. 366: 132-9. PMID: 17157320
- Evidence for a protein X-like domain at the N-terminus of the E1 component of the mammalian 2-oxoglutarate dehydrogenase complex. | Rice, JE. and Lindsay, JG. 1991. Biochem Soc Trans. 19: 403S. PMID: 1794531
- Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. | Bunik, VI. and Degtyarev, D. 2008. Proteins. 71: 874-90. PMID: 18004749
- Establishment and structural analysis of human mAb to the E2 component of the 2-oxoglutarate dehydrogenase complex generated from a patient with primary biliary cirrhosis. | Fukushima, N., et al. 1995. Int Immunol. 7: 1047-55. PMID: 8527402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DHTKD1 Antibody (F-11) | sc-398620 | 200 µg/ml | $322.00 | |||
DHTKD1 Antibody (F-11): m-IgG Fc BP-HRP Bundle | sc-530876 | 200 µg Ab; 10 µg BP | $361.00 | |||
DHTKD1 Antibody (F-11): m-IgGκ BP-HRP Bundle | sc-524427 | 200 µg Ab, 40 µg BP | $361.00 | |||
DHTKD1 Antibody (F-11): m-IgG2b BP-HRP Bundle | sc-550235 | 200 µg Ab; 10 µg BP | $361.00 | |||
DHTKD1 Antibody (F-11) AC | sc-398620 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DHTKD1 Antibody (F-11) HRP | sc-398620 HRP | 200 µg/ml | $322.00 | |||
DHTKD1 Antibody (F-11) FITC | sc-398620 FITC | 200 µg/ml | $336.00 | |||
DHTKD1 Antibody (F-11) PE | sc-398620 PE | 200 µg/ml | $349.00 | |||
DHTKD1 Antibody (F-11) Alexa Fluor® 488 | sc-398620 AF488 | 200 µg/ml | $364.00 | |||
DHTKD1 Antibody (F-11) Alexa Fluor® 546 | sc-398620 AF546 | 200 µg/ml | $364.00 | |||
DHTKD1 Antibody (F-11) Alexa Fluor® 594 | sc-398620 AF594 | 200 µg/ml | $364.00 | |||
DHTKD1 Antibody (F-11) Alexa Fluor® 647 | sc-398620 AF647 | 200 µg/ml | $364.00 | |||
DHTKD1 Antibody (F-11) Alexa Fluor® 680 | sc-398620 AF680 | 200 µg/ml | $364.00 | |||
DHTKD1 Antibody (F-11) Alexa Fluor® 790 | sc-398620 AF790 | 200 µg/ml | $364.00 | |||
DHTKD1 (F-11) Neutralizing Peptide | sc-398620 P | 100 µg/0.5 ml | $69.00 |