DHFR Antibody (49): sc-136246
- DHFR Antibody (49) is a mouse monoclonal IgG1, cited in 4 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-186 of DHFR of bovine origin
- recommended for detection of DHFR of mouse, rat, human, bovine and canine origin by WBIP; not recommended for IP
- See DHFR (A-9): sc-377091 for DHFR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DHFR Antibody (49). This work is in progress.
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SEE ALSO...
DHFR Antibody (49) is a mouse monoclonal IgG1 antibody that detects dihydrofolate reductase (DHFR) in mouse, rat, human, bovine, and canine samples through applications such as western blotting (WB) and immunoprecipitation (IP). DHFR plays a vital role in cellular metabolism by catalyzing the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, which is essential for the synthesis of purines, pyrimidines, and certain amino acids. This enzymatic activity is crucial for DNA synthesis; thus, inhibition of DHFR can lead to cell cycle arrest and apoptosis, making DHFR a significant target in cancer therapy. Notably, the expression of methotrexate-resistant variants of DHFR in normal hematopoietic cells has emerged as a promising strategy to enable the administration of higher doses of methotrexate, as this approach may help mitigate drug toxicity in sensitive normal tissues. DHFR′s ability to interact with various substrates and inhibitors further underscores DHFR′s importance in both normal physiology and disease states, making anti-DHFR antibody (49) an invaluable tool for researchers studying these critical pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DHFR Antibody (49) | sc-136246 | 50 µg/0.5 ml | $316.00 |