DGCR14 Antibody (C-9): sc-398472
- DGCR14 Antibody (C-9) is a mouse monoclonal IgG2a κ DGCR14 antibody provided at 200 µg/ml
- raised against amino acids 177-476 mapping at the C-terminus of DGCR14 of human origin
- DGCR14 Antibody (C-9) is recommended for detection of DGCR14 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DGCR14 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DGCR14 Antibody (C-9) for WB applications. These reagents are now offered in bundles with DGCR14 Antibody (C-9) (see ordering information below).
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DGCR14 Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects DGCR14 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-DGCR14 antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DGCR14, also known as DiGeorge syndrome critical region 14, is a 476 amino acid nuclear protein that plays a crucial role in the etiology of velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder associated with a range of anomalies including structural and functional palate defects, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and characteristic facial features. DGCR14 localizes to the nucleus, where DGCR14 co-purifies with C complex spliceosomes, highlighting potential involvement in RNA splicing and gene regulation. Disruptions in DGCR14 function due to deletions in chromosome 22q11.2 can lead to significant developmental challenges, making DGCR14 a critical target for research in understanding the molecular mechanisms underlying these syndromes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DGCR14 Antibody (C-9) References:
- Functional analysis of polymorphisms in the promoter regions of genes on 22q11. | Hoogendoorn, B., et al. 2004. Hum Mutat. 24: 35-42. PMID: 15221787
- Transmission disequilibrium test provides evidence of association between promoter polymorphisms in 22q11 gene DGCR14 and schizophrenia. | Wang, H., et al. 2006. J Neural Transm (Vienna). 113: 1551-61. PMID: 16432632
- Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans. | Rizzu, P., et al. 1996. Mamm Genome. 7: 639-43. PMID: 8703114
- Structural and mutational analysis of a conserved gene (DGSI) from the minimal DiGeorge syndrome critical region. | Gong, W., et al. 1997. Hum Mol Genet. 6: 267-76. PMID: 9063747
- Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene. | Chieffo, C., et al. 1997. Genomics. 43: 267-77. PMID: 9268629
- ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene. | Lindsay, EA., et al. 1998. Hum Mol Genet. 7: 629-35. PMID: 9499415
- Functional analysis of Gscl in the pathogenesis of the DiGeorge and velocardiofacial syndromes. | Wakamiya, M., et al. 1998. Hum Mol Genet. 7: 1835-40. PMID: 9811926
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DGCR14 Antibody (C-9) | sc-398472 | 200 µg/ml | $322.00 | |||
DGCR14 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-530813 | 200 µg Ab; 10 µg BP | $361.00 | |||
DGCR14 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-524358 | 200 µg Ab, 40 µg BP | $361.00 | |||
DGCR14 Antibody (C-9): m-IgG2a BP-HRP Bundle | sc-547596 | 200 µg Ab; 10 µg BP | $361.00 | |||
DGCR14 Antibody (C-9) AC | sc-398472 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DGCR14 Antibody (C-9) HRP | sc-398472 HRP | 200 µg/ml | $322.00 | |||
DGCR14 Antibody (C-9) FITC | sc-398472 FITC | 200 µg/ml | $336.00 | |||
DGCR14 Antibody (C-9) PE | sc-398472 PE | 200 µg/ml | $349.00 | |||
DGCR14 Antibody (C-9) Alexa Fluor® 488 | sc-398472 AF488 | 200 µg/ml | $364.00 | |||
DGCR14 Antibody (C-9) Alexa Fluor® 546 | sc-398472 AF546 | 200 µg/ml | $364.00 | |||
DGCR14 Antibody (C-9) Alexa Fluor® 594 | sc-398472 AF594 | 200 µg/ml | $364.00 | |||
DGCR14 Antibody (C-9) Alexa Fluor® 647 | sc-398472 AF647 | 200 µg/ml | $364.00 | |||
DGCR14 Antibody (C-9) Alexa Fluor® 680 | sc-398472 AF680 | 200 µg/ml | $364.00 | |||
DGCR14 Antibody (C-9) Alexa Fluor® 790 | sc-398472 AF790 | 200 µg/ml | $364.00 |