Desmin Antibody (B-12): sc-365130
- Desmin Antibody (B-12) is a mouse monoclonal IgA κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 413-445 near the C-terminus of Desmin of human origin
- recommended for detection of Desmin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- See Desmin (RD301): sc-23879 for Desmin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Desmin Antibody (B-12) for WB and IHC(P) applications. This reagent is now offered in a bundle with Desmin Antibody (B-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Desmin Antibody (B-12) is a mouse monoclonal IgA antibody that detects Desmin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Desmin is a crucial intermediate filament protein that plays a significant role in maintaining the structural integrity of muscle cells. Desmin is primarily located near the Z line in sarcomeres, where Desmin forms a network that connects adjacent myofibrils, thereby facilitating the transmission of force during muscle contraction. This structural organization is vital for muscle function, as Desmin ensures that contractile forces generated by sarcomeres are effectively transmitted throughout the muscle fiber. Additionally, proper assembly and function of Desmin are essential for overall muscle tissue health; mutations in the gene encoding Desmin can lead to severe conditions such as adult-onset skeletal myopathy and cardiac issues. Anti-Desmin antibody (B-12) is an invaluable tool for researchers studying muscle development, pathology, and underlying mechanisms of muscle-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Desmin Antibody (B-12) References:
- Transcriptional regulation of the desmin and SM22 genes in vascular smooth muscle cells. | Mericskay, M., et al. 1999. Curr Top Pathol. 93: 7-17. PMID: 10339894
- Desmin mutations in the terminal consensus motif prevent synemin-desmin heteropolymer filament assembly. | Chourbagi, O., et al. 2011. Exp Cell Res. 317: 886-97. PMID: 21262226
- Desmin-positivity in spindle cells: under-recognized immunophenotype of lipoblastoma. | Kubota, F., et al. 2013. Pathol Int. 63: 353-7. PMID: 23865573
- Aggregate-prone desmin mutations impair mitochondrial calcium uptake in primary myotubes. | Smolina, N., et al. 2014. Cell Calcium. 56: 269-75. PMID: 25171807
- Strategies to Study Desmin in Cardiac Muscle and Culture Systems. | Diokmetzidou, A., et al. 2016. Methods Enzymol. 568: 427-59. PMID: 26795479
- Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure. | Rainer, PP., et al. 2018. Circ Res. 122: e75-e83. PMID: 29483093
- Patterns of desmin expression in idiopathic dilated cardiomyopathy are related to the desmin mRNA and ubiquitin expression. | Pawlak, A., et al. 2019. J Investig Med. 67: 11-19. PMID: 30097466
- Knockout of zebrafish desmin genes does not cause skeletal muscle degeneration but alters calcium flux. | Kayman Kürekçi, G., et al. 2021. Sci Rep. 11: 7505. PMID: 33820917
- Absence of Desmin Results in Impaired Adaptive Response to Mechanical Overloading of Skeletal Muscle. | Joanne, P., et al. 2021. Front Cell Dev Biol. 9: 662133. PMID: 34336827
- Functional impact of the head domain variants of DES (Desmin) on filament assembly. | Voß, S., et al. 2025. Genes Dis. 12: 101238. PMID: 39650696
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desmin Antibody (B-12) | sc-365130 | 200 µg/ml | $322.00 | |||
Desmin Antibody (B-12): m-IgGκ BP-HRP Bundle | sc-552338 | 200 µg Ab; 40 µg BP | $361.00 | |||
Desmin (B-12) Neutralizing Peptide | sc-365130 P | 100 µg/0.5 ml | $69.00 |