DENND3 Antibody (A-6): sc-390685
- DENND3 Antibody (A-6) is a mouse monoclonal IgG1 κ DENND3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1169-1192 of DENND3 of human origin
- DENND3 Antibody (A-6) is recommended for detection of DENND3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- Anti-DENND3 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DENND3 Antibody (A-6) for WB applications. These reagents are now offered in bundles with DENND3 Antibody (A-6) (see ordering information below).
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DENND3 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects DENND3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DENND3 Antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DENND3, which consists of 1,198 amino acids, plays a crucial role in cellular signaling and is involved in the regulation of endosomal trafficking and membrane dynamics. DENND3 structure includes a single DENN domain, which is essential for function as a guanine nucleotide exchange factor, facilitating the activation of RAB GTPases that are pivotal in vesicle transport. Proper functioning of DENND3 is vital for maintaining cellular homeostasis, and dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. DENND3 gene is conserved across several species, including chimpanzees, dogs, cows, mice, rats, chickens, and zebrafish, and is located on human chromosome 8q24.3, a region associated with several genetic conditions. Understanding DENND3 and interactions with other proteins can provide insights into significance in health and disease, making anti-DENND3 antibody (A-6) an invaluable tool for researchers studying these pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DENND3 Antibody (A-6) References:
- Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. | Espanel, X. and Sudol, M. 2001. J Biol Chem. 276: 14514-23. PMID: 11278422
- Cytogenetic mapping of a novel locus for type II Waardenburg syndrome. | Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. | McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
- DNA sequence and analysis of human chromosome 8. | Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
- Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis. | Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002
- Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients. | Weber, F., et al. 2012. Pharmacogenomics J. 12: 238-45. PMID: 21502966
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DENND3 Antibody (A-6) | sc-390685 | 200 µg/ml | $322.00 | |||
DENND3 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-530228 | 200 µg Ab; 10 µg BP | $361.00 | |||
DENND3 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-523638 | 200 µg Ab, 40 µg BP | $361.00 | |||
DENND3 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-543941 | 200 µg Ab; 20 µg BP | $361.00 | |||
DENND3 Antibody (A-6) AC | sc-390685 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DENND3 Antibody (A-6) HRP | sc-390685 HRP | 200 µg/ml | $322.00 | |||
DENND3 Antibody (A-6) FITC | sc-390685 FITC | 200 µg/ml | $336.00 | |||
DENND3 Antibody (A-6) PE | sc-390685 PE | 200 µg/ml | $349.00 | |||
DENND3 Antibody (A-6) Alexa Fluor® 488 | sc-390685 AF488 | 200 µg/ml | $364.00 | |||
DENND3 Antibody (A-6) Alexa Fluor® 546 | sc-390685 AF546 | 200 µg/ml | $364.00 | |||
DENND3 Antibody (A-6) Alexa Fluor® 594 | sc-390685 AF594 | 200 µg/ml | $364.00 | |||
DENND3 Antibody (A-6) Alexa Fluor® 647 | sc-390685 AF647 | 200 µg/ml | $364.00 | |||
DENND3 Antibody (A-6) Alexa Fluor® 680 | sc-390685 AF680 | 200 µg/ml | $364.00 | |||
DENND3 Antibody (A-6) Alexa Fluor® 790 | sc-390685 AF790 | 200 µg/ml | $364.00 | |||
DENND3 (A-6) Neutralizing Peptide | sc-390685 P | 100 µg/0.5 ml | $69.00 |