Delta Antibody (E-5): sc-377447
- Delta Antibody (E-5) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 459-723 of Delta of human origin
- recommended for detection of Delta of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Delta Antibody (E-5) for WB applications. This reagent is now offered in a bundle with Delta Antibody (E-5) (see ordering information below).
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Delta Antibody (E-5) is a mouse monoclonal IgG2b antibody that detects Delta in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Delta, a member of the Notch signaling pathway, plays a crucial role in cell communication and differentiation, particularly during embryonic development and organogenesis. Delta anti-Delta antibody (E-5) influences the fate of progenitor cells, guiding them towards specific lineages, such as T cells and natural killer cells, while simultaneously inhibiting B cell lineage differentiation. Delta monoclonal antibody (E-5) expression is found in key tissues, including the heart, pancreas, brain, and muscle during critical developmental stages, as well as in adult heart and lung tissues. Delta′s interaction with ligands such as Jagged and Delta-like proteins further emphasizes Delta (E-5) antibody′s significance in regulating cellular processes and maintaining homeostasis. Delta (E-5) monoclonal antibody serves as an essential tool for researchers investigating the complexities of cell fate decisions and the implications of Notch signaling in various biological contexts.
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Delta Antibody (E-5) References:
- DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. | Sörensen, I., et al. 2009. Blood. 113: 5680-8. PMID: 19144989
- Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. | Chakrabarti, R., et al. 2018. Science. 360: PMID: 29773667
- Host-Derived Delta-Like Canonical Notch Ligand 1 as a Novel Diagnostic Biomarker for Bacterial Sepsis-Results From a Combinational Secondary Analysis. | Hildebrand, D., et al. 2019. Front Cell Infect Microbiol. 9: 267. PMID: 31396491
- Delta-like Canonical Notch Ligand 1 in Patients Following Liver Transplantation-A Secondary Analysis of a Prospective Cohort Study. | Decker, SO., et al. 2020. Diagnostics (Basel). 10: PMID: 33142943
- Activity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo. | Schuster-Gossler, K., et al. 2021. BMC Res Notes. 14: 383. PMID: 34583743
- The role of DLL1 in long-term vascular normalization and cancer immunotherapy. | Wu, Q. and Huang, Y. 2021. Cancer Biol Med. 18: 940-3. PMID: 34708998
- Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium. | Hirano, KI., et al. 2022. Front Immunol. 13: 852427. PMID: 35371023
- Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma. | Chen, L., et al. 2023. Gut. 72: 421-432. PMID: 35750470
- Delta-like canonical Notch ligand 1 is predictive for sepsis and acute kidney injury in surgical intensive care patients. | Schneck, E., et al. 2022. Sci Rep. 12: 13355. PMID: 35922468
- Evaluation of the Novel Sepsis Biomarker Host-Derived Delta-like Canonical Notch Ligand 1-A Secondary Analysis of 405 Patients Suffering from Inflammatory or Infectious Diseases. | Hölle, T., et al. 2023. Int J Mol Sci. 24: PMID: 37298115
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Delta Antibody (E-5) | sc-377447 | 200 µg/ml | $322.00 | |||
Delta Antibody (E-5): m-IgG2b BP-HRP Bundle | sc-548610 | 200 µg Ab; 10 µg BP | $361.00 |