Delta Activators
Delta activators represent a diverse class of compounds that either directly engage with Delta or indirectly modulate its activity within the intricate Notch signaling pathway. The Notch pathway, essential for cellular communication and differentiation, relies on the dynamic interplay between Notch receptors and their ligands, including Delta. Understanding the pharmacological impact of Delta activators is crucial for unraveling the complexities of Notch signaling and its physiological implications. Direct Delta activators, such as DAPT, Compound E, RO4929097, DBZ, LY411575, L685,458, and Dibenzazepine play pivotal roles in modulating Delta's function. γ-secretase inhibitors like DAPT, Compound E, RO4929097, DBZ, LY411575, L685,458, Dibenzazepine (DBZ), and IX-01 indirectly activate Delta by impeding its cleavage, influencing downstream Notch signaling. These compounds offer precise tools for dissecting Delta-associated pathways and understanding the regulatory mechanisms governing Notch activation.
In contrast, synthetic peptides mimicking the Notch ligands, Jagged-1 Peptide and Jagged-2 Peptide, as well as antibodies against Jagged-1 and Jagged-2, directly engage with Delta's extracellular domain, initiating Notch signaling. These compounds shed light on the intricacies of Delta as a ligand and its role in orchestrating cellular fate decisions. The diverse mechanisms through which Delta activators operate underscore the complexity of Notch signaling and offer valuable insights for researchers. These compounds serve as indispensable tools for unraveling the tapestry of Delta-mediated processes, paving the way for future discoveries in cell biology
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT, a γ-secretase inhibitor, indirectly activates Delta by blocking its cleavage. Inhibition of γ-secretase preserves Delta on the cell surface, enhancing Notch signaling. DAPT's impact on the Notch pathway provides insights into Delta-mediated cellular processes and potential therapeutic applications. | ||||||
Compound E | 209986-17-4 | sc-221433 sc-221433A sc-221433B | 250 µg 1 mg 5 mg | $124.00 $342.00 $967.00 | 12 | |
Compound E, another γ-secretase inhibitor, indirectly activates Delta by preventing its cleavage. Inhibition of γ-secretase stabilizes Delta on cell membranes, modulating Notch signaling. Compound E's pharmacological properties offer a valuable tool for dissecting Delta-related pathways and exploring potential therapeutic interventions involving the Notch pathway. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $439.00 $1417.00 | 1 | |
RO4929097, a selective γ-secretase inhibitor, indirectly activates Delta by inhibiting its cleavage. Modulation of γ-secretase activity influences Delta's role in Notch signaling. RO4929097's specificity for γ-secretase makes it a crucial compound for investigating Delta-mediated processes and potential therapeutic strategies targeting the Notch pathway. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $235.00 $260.00 | 4 | |
DBZ, a γ-secretase inhibitor, indirectly activates Delta by preventing its cleavage. Inhibition of γ-secretase alters Delta's processing, impacting Notch signaling. DBZ's pharmacological profile provides a tool for dissecting Delta-associated pathways, contributing to our understanding of the intricacies of Notch signaling and its implications in cellular regulation. | ||||||
L-685,458 | 292632-98-5 | sc-204042 sc-204042A | 1 mg 5 mg | $337.00 $1000.00 | 4 | |
L685,458, a γ-secretase inhibitor, indirectly activates Delta by blocking its cleavage. Inhibition of γ-secretase modulates Delta processing, impacting Notch signaling. L685,458's pharmacological properties make it an essential compound for dissecting Delta-associated pathways, contributing to our understanding of Notch signaling complexities and potential therapeutic applications targeting aberrant Notch activity. | ||||||