DDX41 Antibody (C-3): sc-166225
- DDX41 Antibody (C-3) is a mouse monoclonal IgG2a κ DDX41 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 111-206 mapping within an internal region of DDX41 of human origin
- DDX41 Antibody (C-3) is recommended for detection of DDX41 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DDX41 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-166225 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DDX41 Antibody (C-3) for WB applications. These reagents are now offered in bundles with DDX41 Antibody (C-3) (see ordering information below).
DDX41 Antibody (C-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects DDX41 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DDX41 (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DDX41, also known as probable ATP-dependent RNA helicase DDX41, is a 622 amino acid protein encoded by the human gene DDX41. DDX41 is a member of the DEAD box helicase family and features a CCHC-type zinc finger, a helicase ATP-binding domain, and a helicase C-terminal domain, which are crucial for function. DDX41 plays a significant role in post-transcriptional gene expression, particularly in pre-mRNA splicing, making DDX41 essential for proper processing of RNA molecules. DDX41′s helicase activity is vital as DDX41 unwinds RNA structures, facilitating various biological processes such as transcription, splicing, and translation. By understanding DDX41′s function and interactions within cells, researchers can gain insights into regulatory mechanisms of gene expression and potential implications in diseases associated with RNA processing.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DDX41 Antibody (C-3) References:
- Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt. | Irion, U. and Leptin, M. 1999. Curr Biol. 9: 1373-81. PMID: 10607561
- RNA helicases: regulators of differentiation. | Abdelhaleem, M. 2005. Clin Biochem. 38: 499-503. PMID: 15885226
- Phosphoproteome analysis of the human mitotic spindle. | Nousiainen, M., et al. 2006. Proc Natl Acad Sci U S A. 103: 5391-6. PMID: 16565220
- Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms. | Polprasert, C., et al. 2015. Cancer Cell. 27: 658-70. PMID: 25920683
- Germline DDX41 mutations define a significant entity within adult MDS/AML patients. | Sébert, M., et al. 2019. Blood. 134: 1441-1444. PMID: 31484648
- DDX41 is required for cGAS-STING activation against DNA virus infection. | Singh, RS., et al. 2022. Cell Rep. 39: 110856. PMID: 35613581
- The genetic landscape of germline DDX41 variants predisposing to myeloid neoplasms. | Li, P., et al. 2022. Blood. 140: 716-755. PMID: 35671390
- Germ line DDX41 mutations define a unique subtype of myeloid neoplasms. | Makishima, H., et al. 2023. Blood. 141: 534-549. PMID: 36322930
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DDX41 Antibody (C-3) | sc-166225 | 200 µg/ml | $322.00 | |||
DDX41 Antibody (C-3): m-IgG Fc BP-HRP Bundle | sc-528924 | 200 µg Ab; 10 µg BP | $361.00 | |||
DDX41 Antibody (C-3): m-IgGκ BP-HRP Bundle | sc-521538 | 200 µg Ab, 40 µg BP | $361.00 | |||
DDX41 Antibody (C-3): m-IgG2a BP-HRP Bundle | sc-547206 | 200 µg Ab; 10 µg BP | $361.00 | |||
DDX41 Antibody (C-3) X | sc-166225 X | 200 µg/0.1 ml | $322.00 | |||
DDX41 Antibody (C-3) AC | sc-166225 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DDX41 Antibody (C-3) HRP | sc-166225 HRP | 200 µg/ml | $322.00 | |||
DDX41 Antibody (C-3) FITC | sc-166225 FITC | 200 µg/ml | $336.00 | |||
DDX41 Antibody (C-3) PE | sc-166225 PE | 200 µg/ml | $349.00 | |||
DDX41 Antibody (C-3) Alexa Fluor® 488 | sc-166225 AF488 | 200 µg/ml | $364.00 | |||
DDX41 Antibody (C-3) Alexa Fluor® 546 | sc-166225 AF546 | 200 µg/ml | $364.00 | |||
DDX41 Antibody (C-3) Alexa Fluor® 594 | sc-166225 AF594 | 200 µg/ml | $364.00 | |||
DDX41 Antibody (C-3) Alexa Fluor® 647 | sc-166225 AF647 | 200 µg/ml | $364.00 | |||
DDX41 Antibody (C-3) Alexa Fluor® 680 | sc-166225 AF680 | 200 µg/ml | $364.00 | |||
DDX41 Antibody (C-3) Alexa Fluor® 790 | sc-166225 AF790 | 200 µg/ml | $364.00 |