DD3 Antibody (D-9): sc-398596
- DD3 Antibody (D-9) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 291-323 at the C-terminus of DD3 of human origin
- recommended for detection of DD3 of human origin and AKR1C18 of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DD3 Antibody (D-9) for WB applications. These reagents are now offered in bundles with DD3 Antibody (D-9) (see ordering information below).
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DD3 Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects dihydrodiol dehydrogenase 3 (DD3) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DD3, also known as AKR1C3, is a member of the aldo-keto reductase superfamily and plays a crucial role in steroid and xenobiotic metabolism. DD3 (D-9) antibody recognizes an enzyme that catalyzes the reduction of 3-keto-5-dihydrosteroids, essential for regulating steroid hormone levels in the body. DD3 maintains hormonal balance and influences various physiological processes, including reproduction and metabolism. Among its isoforms, DD3 uniquely catalyzes the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol, highlighting specialized function in detoxifying environmental pollutants. DD3 expression is predominantly found in the liver, where anti-DD3 antibody (D-9) helps researchers study drug biotransformation and compound metabolism, making DD3 a significant target for drug metabolism and toxicology studies. With broad species reactivity and versatile applications, DD3 monoclonal antibody (D-9) serves as an invaluable tool for investigating dihydrodiol dehydrogenases in various biological contexts.
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DD3 Antibody (D-9) References:
- DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. | Bussemakers, MJ., et al. 1999. Cancer Res. 59: 5975-9. PMID: 10606244
- DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. | Hessels, D., et al. 2003. Eur Urol. 44: 8-15; discussion 15-6. PMID: 12814669
- Identification of PCA3 (DD3) in prostatic carcinoma by in situ hybridization. | Popa, I., et al. 2007. Mod Pathol. 20: 1121-7. PMID: 17873893
- The combination of urine DD3(PCA3) mRNA and PSA mRNA as molecular markers of prostate cancer. | Mearini, E., et al. 2009. Biomarkers. 14: 235-43. PMID: 19489685
- Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene. | Fan, JK., et al. 2010. Int J Cancer. 127: 707-17. PMID: 19950222
- Differential display code 3 (DD3/PCA3) in prostate cancer diagnosis. | Klecka, J., et al. 2010. Anticancer Res. 30: 665-70. PMID: 20332487
- Prostate cancer-specific and potent antitumor effect of a DD3-controlled oncolytic virus harboring the PTEN gene. | Ding, M., et al. 2012. PLoS One. 7: e35153. PMID: 22509396
- Prostate Cancer-Specific of DD3-driven Oncolytic Virus-harboring mK5 Gene. | Hao, J., et al. 2019. Open Med (Wars). 14: 1-9. PMID: 30613790
- Effect of upregulation of DD3 on early detection and prognosis in prostate cancer. | Wang, K., et al. 2020. Transl Androl Urol. 9: 1550-1558. PMID: 32944517
- Oncolytic Adenovirus with SPAG9 shRNA Driven by DD3 Promoter Improved the Efficacy of Docetaxil for Prostate Cancer. | Lu, M., et al. 2022. J Oncol. 2022: 7918067. PMID: 35535313
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DD3 Antibody (D-9) | sc-398596 | 200 µg/ml | $322.00 | |||
DD3 Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-538476 | 200 µg Ab; 10 µg BP | $361.00 | |||
DD3 Antibody (D-9): m-IgGκ BP-HRP Bundle | sc-536098 | 200 µg Ab; 40 µg BP | $361.00 | |||
DD3 Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-545720 | 200 µg Ab; 20 µg BP | $361.00 | |||
DD3 (D-9) Neutralizing Peptide | sc-398596 P | 100 µg/0.5 ml | $69.00 |