DC-SIGNR Antibody (G-8): sc-393435

DC-SIGNR Antibody (G-8) is a mouse monoclonal IgG2a light chain antibody that detects DC-SIGNR in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DC-SIGNR, also known as CD209L or L-SIGN, is a type II integral membrane protein that shares 77% identity with DC-SIGN and is primarily expressed on sinusoidal endothelial cells. Anti-DC-SIGNR antibody (G-8) recognizes a protein that plays a crucial role in the immune response by binding to E2 glycoproteins of hepatitis C virus, facilitating viral entry into host cells. The interaction between DC-SIGNR and hepatitis C virus is significant as this binding not only aids in virus evasion of the immune system but also contributes to infection pathogenesis. Understanding DC-SIGNR function is essential for developing therapeutic strategies against hepatitis C, as targeting this interaction could potentially hinder viral dissemination and improve patient outcomes. DC-SIGNR monoclonal antibody (G-8) serves as an invaluable tool for researchers studying viral infection mechanisms and immune response.

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DC-SIGNR Antibody (G-8) References:

1. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.  |  Mitchell, DA., et al. 2001. J Biol Chem. 276: 28939-45. PMID: 11384997
2. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.  |  Feinberg, H., et al. 2001. Science. 294: 2163-6. PMID: 11739956
3. Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR.  |  Parent, SA., et al. 2002. Gene. 293: 33-46. PMID: 12137941
4. Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.  |  Soilleux, EJ., et al. 2002. Hum Pathol. 33: 652-9. PMID: 12152166
5. Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.  |  Feinberg, H., et al. 2005. J Biol Chem. 280: 1327-35. PMID: 15509576
6. The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.  |  Nattermann, J., et al. 2006. J Viral Hepat. 13: 42-6. PMID: 16364081
7. The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.  |  Marzi, A., et al. 2006. J Virol. 80: 6305-17. PMID: 16775318
8. DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility.  |  Boily-Larouche, G., et al. 2007. Hum Immunol. 68: 523-30. PMID: 17509452
9. Frontal affinity chromatography analysis of constructs of DC-SIGN, DC-SIGNR and LSECtin extend evidence for affinity to agalactosylated N-glycans.  |  Yabe, R., et al. 2010. FEBS J. 277: 4010-26. PMID: 20840590
10. The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysis.  |  Li, H., et al. 2012. PLoS One. 7: e42972. PMID: 22957026

The preferred DC-SIGN/DC-SIGNR antibody is DC-SIGN/DC-SIGNR Antibody (B-2): sc-74589.