DC-SIGNR Antibody (C-10): sc-271086

DC-SIGNR Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects DC-SIGNR of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-DC-SIGNR antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DC-SIGNR, also known as CD209L or L-SIGN, is a type II integral membrane protein sharing 77% sequence identity with DC-SIGN and is primarily expressed on sinusoidal endothelial cells. DC-SIGNR (C-10) antibody recognizes a protein that plays a crucial role in immune response by binding to E2 glycoproteins of hepatitis C virus, facilitating viral entry into host cells. DC-SIGNR′s interaction with hepatitis C virus aids in viral evasion of immune system and enhances viral infection of liver cells, which are critical for viral replication and persistence. Understanding DC-SIGNR′s function is essential for developing therapeutic strategies against hepatitis C and other viral infections, making DC-SIGNR monoclonal antibody (C-10) a valuable research tool for studying these processes.

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DC-SIGNR Antibody (C-10) References:

1. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.  |  Yokoyama-Kobayashi, M., et al. 1999. Gene. 228: 161-7. PMID: 10072769
2. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.  |  Soilleux, EJ., et al. 2000. J Immunol. 165: 2937-42. PMID: 10975799
3. DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.  |  Pöhlmann, S., et al. 2001. Proc Natl Acad Sci U S A. 98: 2670-5. PMID: 11226297
4. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.  |  Bashirova, AA., et al. 2001. J Exp Med. 193: 671-8. PMID: 11257134
5. The role of DC-SIGN and DC-SIGNR in HIV and SIV attachment, infection, and transmission.  |  Baribaud, F., et al. 2001. Virology. 286: 1-6. PMID: 11448153
6. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.  |  Lai, WK., et al. 2006. Am J Pathol. 169: 200-8. PMID: 16816373
7. DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection.  |  Zhang, F., et al. 2014. Int Rev Immunol. 33: 54-66. PMID: 24156700
8. The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer.  |  Jiang, Y., et al. 2014. PLoS One. 9: e114748. PMID: 25504222
9. Association of DC-SIGNR Expression in Peripheral Blood Mononuclear Cells with DC-SIGNR Genotypes in HIV-1 Infection.  |  Chaudhary, O., et al. 2015. Viral Immunol. 28: 472-5. PMID: 26313015
10. Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis.  |  Na, H., et al. 2017. J Hematol Oncol. 10: 28. PMID: 28109307
11. DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis.  |  Zhang, Y., et al. 2017. Mol Cancer. 16: 78. PMID: 28403883
12. Host factors and the pathogenesis of HIV-induced disease.  |  Fauci, AS. 1996. Nature. 384: 529-34. PMID: 8955267

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DC-SIGNR Antibody (C-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DC-SIGNR Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DC-SIGNR Antibody (C-10) Specifications

Alternate Product Name: DC-SIGNR

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 12-41

Epitope Target: DC-SIGNR

Epitope Species: human

Product Reactivity/Detection: DC-SIGNR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DC-SIGNR Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred DC-SIGN/DC-SIGNR antibody is DC-SIGN/DC-SIGNR Antibody (B-2): sc-74589.