DC-SIGN Antibody (9E9A8): sc-53967
- DC-SIGN Antibody (9E9A8) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against DC-SIGN of human origin
- recommended for detection of DC-SIGN of human origin by WB and IF
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DC-SIGN Antibody (9E9A8) for WB applications. These reagents are now offered in bundles with DC-SIGN Antibody (9E9A8) (see ordering information below).
DC-SIGN Antibody (9E9A8) is a mouse monoclonal IgG2a antibody that detects DC-SIGN in human samples through applications such as western blotting (WB) and immunofluorescence (IF). DC-SIGN, also known as CD209, is a type II membrane protein predominantly expressed on dendritic cells, which play a crucial role in the immune response by presenting antigens to T cells. The unique structure of DC-SIGN, featuring a C-type lectin domain, allows specific binding to various pathogens, including HIV-1, facilitating their capture and transport from mucosal surfaces to lymphoid tissues. This interaction is vital for initiating immune responses, as DC-SIGN enables dendritic cells to efficiently present viral antigens to T cells, thereby promoting adaptive immunity. The ability of DC-SIGN to mediate the initial contact between dendritic cells and resting T cells underscores its importance in the immunological synapse, making DC-SIGN a key player in the body′s defense against infections. Anti-DC-SIGN antibody (9E9A8) serves as an essential tool for researchers studying immune responses and pathogen interactions.
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DC-SIGN Antibody (9E9A8) References:
- A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance. | van Kooyk, Y., et al. 2003. Trends Mol Med. 9: 153-9. PMID: 12727141
- DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. | Geijtenbeek, TB. and van Kooyk, Y. 2003. Curr Top Microbiol Immunol. 276: 31-54. PMID: 12797442
- Innate signaling by the C-type lectin DC-SIGN dictates immune responses. | den Dunnen, J., et al. 2009. Cancer Immunol Immunother. 58: 1149-57. PMID: 18998127
- Effects of rapamycin on DC-SIGN expression and biological functions in DC. | Chen, J., et al. 2014. Front Biosci (Landmark Ed). 19: 557-65. PMID: 24389203
- Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods. | Kamalakannan, M., et al. 2016. Allergy. 71: 1145-55. PMID: 26948687
- DC-SIGN promotes allergen uptake and activation of dendritic cells in patients with atopic dermatitis. | Zhang, Y., et al. 2016. J Dermatol Sci. 84: 128-136. PMID: 27554335
- Association of Single-Nucleotide Polymorphisms in DC-SIGN with Nasopharyngeal Carcinoma Susceptibility. | Li, S., et al. 2017. Dis Markers. 2017: 6309754. PMID: 28694559
- SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues. | Cai, G., et al. 2021. Int J Mol Sci. 22: PMID: 34502134
- Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN. | Cramer, J. 2021. RSC Med Chem. 12: 1985-2000. PMID: 35024612
- IRF7 Exacerbates Candida albicans Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages. | Qing, F., et al. 2024. J Immunol. 212: 1932-1944. PMID: 38709167
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DC-SIGN Antibody (9E9A8) | sc-53967 | 200 µg/ml | $322.00 | |||
DC-SIGN Antibody (9E9A8): m-IgG Fc BP-HRP Bundle | sc-537022 | 200 µg Ab; 10 µg BP | $361.00 | |||
DC-SIGN Antibody (9E9A8): m-IgGκ BP-HRP Bundle | sc-534204 | 200 µg Ab; 40 µg BP | $361.00 | |||
DC-SIGN Antibody (9E9A8): m-IgG2a BP-HRP Bundle | sc-547915 | 200 µg Ab; 10 µg BP | $361.00 |