D-Glucose 6-phosphate potassium salt (CAS 103192-55-8)

D-Glucose 6-phosphate potassium salt, a key intermediate in glucose metabolism, plays critical roles in cellular energy production and biosynthetic pathways, making it a subject of extensive research in various scientific fields. Upon entry into cells, D-Glucose 6-phosphate potassium salt is phosphorylated by hexokinase to form D-glucose 6-phosphate, a reaction that serves as the first step in glycolysis, the central pathway for glucose catabolism. This phosphorylation not only traps glucose within the cell but also primes it for further metabolic processing. D-Glucose 6-phosphate potassium salt acts as a substrate for various enzymes, including glucose-6-phosphate isomerase, which catalyzes its conversion to fructose 6-phosphate, a crucial step in glycolysis. Additionally, D-Glucose 6-phosphate potassium salt is a precursor for the pentose phosphate pathway, where it undergoes oxidative decarboxylation by glucose-6-phosphate dehydrogenase, generating NADPH and ribose 5-phosphate. NADPH serves as a reducing agent in biosynthetic reactions and plays essential roles in cellular defense against oxidative stress. Ribose 5-phosphate, on the other hand, contributes to nucleotide synthesis and the production of important biomolecules such as nucleic acids and coenzymes. Furthermore, research has explored the involvement of D-Glucose 6-phosphate potassium salt in glucose homeostasis, glycogen synthesis, and insulin signaling pathways, shedding light on its significance in cellular physiology and metabolism. Studies employing isotopic labeling techniques and enzymatic assays have explaind its metabolic fate and regulatory roles in diverse cellular processes, further emphasizing its importance as a fundamental molecule in biological research.